PITX3

Gene Symbol	PITX3
Entrez Gene	5309
Alt Symbol	ASMD, ASOD, CTPP4, CTRCT11, PTX3
Species	Human
Gene Type	protein-coding
Description	paired-like homeodomain 3
Other Description	homeobox protein PITX3|pituitary homeobox 3
Swissprots	Q5VZL2 O75364
Accessions	AJF45881 AJF45882 AJF45883 AJF45884 AJF45885 AJF45886 AJF45887 AJF45888 AJF45889 AJF45890 AJF45891 AJF45892 AJF45893 AJF45894 AJF45895 AJF45896 AJF45897 AJF45898 AJP06693 AJP06694 AJP06695 AJP06696 AJP06697 AJP06698 AJP06699 AJP06700 EAW49709 EAW49710 O75364 AF041339 AAC24502 BC011642 AAH11642 DQ891945 ABM82871 DQ895131 ABM86057 DQ895132 ABM86058 XM_011539865 XP_011538167 NM_005029 NP_005020
Function	Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. In addition to its importance during development, it also has roles in the long-term survival and maintenance of the mdDA neurons. Activates NR4A2/NURR1- mediated transcription of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons. Acts by decreasing the interaction of NR4A2/NURR1 with the corepressor NCOR2/SMRT which acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state. Essential for the normal lens development and differentiation. Plays a critical role in the maintenance of mitotic activity of lens epithelial cells, fiber cell differentiation and in the control of the temporal and spatial activation of fiber cell-specific crystallins. Positively regulates FOXE3 expression and negatively regulates PROX1 in the anterior len
Subcellular Location	Nucleus {ECO:0000255|PROSITE- ProRule:PRU00108, ECO:0000255|PROSITE-ProRule:PRU00138}.
Tissue Specificity	Highly expressed in developing eye lens.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human PITX3 peptide - ab31696 from Abcam Category Peptide

PITX3 Antibody Blocking Peptide - LS-E11634 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PITX3 Antibody Blocking Peptide - LS-E11635 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PITX3 Antibody Blocking Peptide - LS-E13865 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PITX3 Antibody Blocking Peptide - LS-E26583 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PITX3 blocking peptide - GTX88644-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

PITX3 Peptide - AC21-1419-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

PITX3 Peptide - 46-197P from ProSci Category Peptide Species Human

PITX3 fusion protein - ag10038 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

PITX3 fusion protein - ag9867 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human Pituitary homeobox 3(PITX3) - CSB-YP018044HU CSB-EP018044HU CSB-BP018044HU CSB-MP018044HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Pituitary homeobox 3 (PITX3), Recombinant Protein - MBS1239637 from MyBioSource Category Protein Prices $1,655.00, $1,655.00, $2,115.00, $2,115.00 Sizes 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

PITX3, Peptide - MBS427168 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human

Ptx3, PITX3, Peptide - MBS658478 from MyBioSource Category Peptide Prices $290.00 Sizes 1 mg Species Human, Rodent

Ptx3, PITX3, Peptide - MBS659062 from MyBioSource Category Peptide Prices $290.00 Sizes 1 mg Species Human, Rodent

PITX3 Recombinant Protein Antigen - NBP1-92274PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

PITX3-Antibody-N-term-Blocking-Peptide - BP6969a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PITX3 Peptide, Human - M34GP11827H from Creative Peptides Category Peptide Source Synthetic. Species Human

PITX3 Immunizing peptide - orb55006 from Biorbyt Category Peptide

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