| Gene Symbol | DBN1 |
|---|---|
| Entrez Gene | 1627 |
| Alt Symbol | D0S117E |
| Species | Human |
| Gene Type | protein-coding |
| Description | drebrin 1 |
| Other Description | developmentally-regulated brain protein|drebrin|drebrin E|drebrin E2|drebrin-1 |
| Swissprots | B2RBG0 A8MV58 Q9UFZ5 Q16643 |
| Accessions | EAW84989 EAW84990 EAW84991 EAW84992 EAW84993 Q16643 AI683844 AK094125 BAG52819 AK225523 AK295295 BAH12026 AK314645 BAG37207 AL110225 CAB53683 AM393436 CAL38314 AW950551 BC000283 AAH00283 BC007281 AAH07281 BC007567 AAH07567 BC114553 BF205663 D17530 BAA04480 DA245346 DR158741 U00802 AAA16256 XM_005265827 XP_005265884 XM_005265828 XP_005265885 XM_005265829 XP_005265886 XM_006714826 XP_006714889 XM_011534446 XP_011532748 XM_011534447 XP_011532749 NM_004395 NP_004386 NM_080881 NP_543157 |
| Function | Drebrins might play some role in cell migration, extension of neuronal processes and plasticity of dendrites. Required for actin polymerization at immunological synapses (IS) and for CXCR4 recruitment to IS. {ECO:0000269|PubMed:20215400}. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:20215400}. Cytoplasm, cell cortex {ECO:0000269|PubMed:20215400}. Cell junction {ECO:0000269|PubMed:20215400}. Note=In the absence of antigen, evenly distributed throughout subcortical regions of the T-cell membrane and cytoplasm. In the presence of antigen, distributes to the immunological synapse forming at the T-cell-APC contact area, where it localizes at the peripheral and distal supramolecular activation clusters (SMAC). |
| Tissue Specificity | Brain neurons. Also found in the heart, placenta, skeletal muscle, kidney and pancreas. Expressed in peripheral blood lymphocytes, including T-cells (at protein level). {ECO:0000269|PubMed:20215400}. |
Drebrin CRISPR/Cas9 KO Plasmid (h) - sc-403241 from Santa Cruz Biotechnology
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Drebrin HDR Plasmid (h) - sc-403241-HDR from Santa Cruz Biotechnology
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Drebrin Double Nickase Plasmid (h) - sc-403241-NIC from Santa Cruz Biotechnology
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Drebrin Double Nickase Plasmid (h2) - sc-403241-NIC-2 from Santa Cruz Biotechnology
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Drebrin CRISPR Activation Plasmid (h) - sc-403241-ACT from Santa Cruz Biotechnology
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Drebrin CRISPR Activation Plasmid (h2) - sc-403241-ACT-2 from Santa Cruz Biotechnology
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Drebrin Lentiviral Activation Particles (h) - sc-403241-LAC from Santa Cruz Biotechnology
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Drebrin Lentiviral Activation Particles (h2) - sc-403241-LAC-2 from Santa Cruz Biotechnology
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Drebrin siRNA (h) - sc-43731 from Santa Cruz Biotechnology
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Drebrin shRNA Plasmid (h) - sc-43731-SH from Santa Cruz Biotechnology
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Drebrin shRNA (h) Lentiviral Particles - sc-43731-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU087131 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6948 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6948 from Sigma-Aldrich
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DBN1 siRNA (Human) - CRH1144 from Cohesion Biosciences
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DBN1 - MBS8205422 from MyBioSource
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shRNA set against Human DBN1 (NM_004395.3) - SHH274745 from Creative biogene
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shRNA set against Human DBN1(NM_004395.3) - SHG222491 from Creative biogene
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shRNA set against Human DBN1(NM_080881.2) - SHG222733 from Creative biogene
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Drebrin CRISPR/Cas9 KO Plasmid (h2) - sc-403241-KO-2 from Santa Cruz Biotechnology
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Drebrin HDR Plasmid (h2) - sc-403241-HDR-2 from Santa Cruz Biotechnology
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Human DBN1 siRNA - orb261646 from Biorbyt
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DBN1 shRNA Plasmid (Human) - CHH1144 from Cohesion Biosciences
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DBN1 miRNA 3'UTR clone - MiUTR1H-02678 from Creative biogene
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DBN1 miRNA 3'UTR clone - MiUTR1H-02679 from Creative biogene
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