| Gene Symbol | Pmch |
|---|---|
| Entrez Gene | 24659 |
| Alt Symbol | - |
| Species | Rat |
| Gene Type | protein-coding |
| Description | pro-melanin-concentrating hormone |
| Other Description | pro-MCH |
| Swissprots | P14200 |
| Accessions | AAA41581 EDM17019 P14200 FQ214578 M29712 AAA41580 NM_012625 NP_036757 |
| Function | MCH inhibits ACTH secretion at the end of the light on period which corresponds to the peak of the circadian rhythm in ACTH. Inhibits also stress induced ACTH release during the light off period of the cycle. Involved as a neurotransmitter or neuromodulator in a broad array of neuronal functions. Stimulates sexual behavior when injected into the ventromedial nucleus, this effect is antagonized by NEI. In the medial preoptic area, stimulates anxiety and sexual behavior. Antagonizes inhibitory effect of melanotropin alpha on exploration behavior. |
| Subcellular Location | Secreted. |
| Tissue Specificity | MCH is present in all regions of the brain and in neurointermediate lobe of the pituarity gland, with highest concentrations in the hypothalamus. Also expressed to a much lesser extent in stomach, lamina propria of both duodenum and colon, ovary, thymus, pancreas, adrenal gland and testis (spermatogonia, early spermatocytes and Sertoli cells). Weak expression in heart and lung. The other peptides are expressed at least in Sertoli cells, nei being also expressed in brain, stomach and proximal duodenum. In brain exclusively mature mch and nei peptides are present. In peripheral tissues a large product, encompassing the NEI and MCH domains of the precursor, is found predominantly. At low levels fully processed MCH and NEI peptides are present in gut. No expression in peripheral blood. {ECO:0000269|PubMed:7617126, ECO:0000269|PubMed:7783849, ECO:0000269|PubMed:8593803}. |
Neuropeptide Ei-Nh2 Antibody - NB100-64637 from Novus Biologicals
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Rat NEI-NH2 Antibody - GWB-556AD5 from Genway Biotech
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Anti-NEUROPEPTIDE EI-NH2 polyclonal antibody - CPBT-66135RR from Creative Diagnostics
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NEUROPEPTIDE EI-NH2 - MBS222371 from MyBioSource
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Pmch Antibody (OASA08690) - OASA08690 from Aviva Systems Biology
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PMCH antibody - GTX11141 from GeneTex
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