Pmch

Gene Symbol Pmch
Entrez Gene 24659
Alt Symbol -
Species Rat
Gene Type protein-coding
Description pro-melanin-concentrating hormone
Other Description pro-MCH
Swissprots P14200
Accessions AAA41581 EDM17019 P14200 FQ214578 M29712 AAA41580 NM_012625 NP_036757
Function MCH inhibits ACTH secretion at the end of the light on period which corresponds to the peak of the circadian rhythm in ACTH. Inhibits also stress induced ACTH release during the light off period of the cycle. Involved as a neurotransmitter or neuromodulator in a broad array of neuronal functions. Stimulates sexual behavior when injected into the ventromedial nucleus, this effect is antagonized by NEI. In the medial preoptic area, stimulates anxiety and sexual behavior. Antagonizes inhibitory effect of melanotropin alpha on exploration behavior.
Subcellular Location Secreted.
Tissue Specificity MCH is present in all regions of the brain and in neurointermediate lobe of the pituarity gland, with highest concentrations in the hypothalamus. Also expressed to a much lesser extent in stomach, lamina propria of both duodenum and colon, ovary, thymus, pancreas, adrenal gland and testis (spermatogonia, early spermatocytes and Sertoli cells). Weak expression in heart and lung. The other peptides are expressed at least in Sertoli cells, nei being also expressed in brain, stomach and proximal duodenum. In brain exclusively mature mch and nei peptides are present. In peripheral tissues a large product, encompassing the NEI and MCH domains of the precursor, is found predominantly. At low levels fully processed MCH and NEI peptides are present in gut. No expression in peripheral blood. {ECO:0000269|PubMed:7617126, ECO:0000269|PubMed:7783849, ECO:0000269|PubMed:8593803}.

Melanin-Concentrating-Hormone-rat - SP2587b from Abgent, a WuXi AppTec company

Category Peptide
Prices $215.00
Sizes 1 mg
Species Rat

Melanin-Concentrating-Hormone-rat - SP2587a from Abgent, a WuXi AppTec company

Category Peptide
Prices $125.00
Sizes 500 µg
Species Rat

Melanin Concentrating Hormone Rat - GWB-1F828C from Genway Biotech

Category Peptide
Prices $190.00, $310.00
Sizes 500 µg, 1 mg
Species Rat

Recombinant Rat Pro-MCH(Pmch) - CSB-YP018230RA CSB-EP018230RA CSB-BP018230RA CSB-MP018230RA from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Rat

Pro-MCH (Pmch), Recombinant Protein - MBS952215 from MyBioSource

Category Protein
Prices $885.00, $885.00, $1,105.00, $1,105.00, $1,295.00, $1,295.00, $1,750.00, $1,750.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Rat

Recombinant Rat PMCH Protein - PMCH-4540R from Creative Biomart

Category Protein
Source Mammalian Cells
Species Rat
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