Gene Symbol | COL12A1 |
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Entrez Gene | 1303 |
Alt Symbol | BA209D8.1, COL12A1L, DJ234P15.1 |
Species | Human |
Gene Type | protein-coding |
Description | collagen, type XII, alpha 1 |
Other Description | collagen alpha-1(XII) chain|collagen type XII proteoglycan |
Swissprots | Q5VYK2 Q71UR3 O43853 Q15955 Q99715 Q5VYK1 Q99716 |
Accessions | AAC83578 EAW48748 EAW48749 EAW48750 Q99715 AI752603 AJ420501 AK057081 AK307558 BC034534 BC034715 BC050587 AAH50587 BC146868 AAI46869 BP286308 DA661773 U68139 AAC01506 U73778 AAC51244 U73779 AAD40483 XM_011535434 XP_011533736 XM_011535435 XP_011533737 XM_011535436 XP_011533738 NM_004370 NP_004361 NM_080645 NP_542376 |
Function | Type XII collagen interacts with type I collagen- containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix. {ECO:0000250}. |
Subcellular Location | Secreted, extracellular space, extracellular matrix {ECO:0000250}. |
Tissue Specificity | Found in collagen I-containing tissues: both isoform 1 and isoform 2 appear in amnion, chorion, skeletal muscle, small intestine, and in cell culture of dermal fibroblasts, keratinocytes and endothelial cells. Only isoform 2 is found in lung, placenta, kidney and a squamous cell carcinoma cell line. Isoform 1 is also present in the corneal epithelial Bowman's membrane (BM) and the interfibrillar matrix of the corneal stroma, but it is not detected in the limbal BM. {ECO:0000269|PubMed:9344363}. |
Top Pathways | Protein digestion and absorption |
Recombinant Collagen Type XII (COL12) - RPC158Hu01 from Uscn Life Science Inc.
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Recombinant Collagen Type XII (COL12) - RPC158Mu01 from Uscn Life Science Inc.
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Recombinant Collagen Type XII (COL12) - RPC158Mu02 from Uscn Life Science Inc.
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Recombinant Collagen Type XII (COL12) - RPC158Ra01 from Uscn Life Science Inc.
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Recombinant Collagen Type XII (COL12) - RPC158Hu01 from Cloud-clone
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Recombinant Human Collagen alpha-1(XII) chain(COL12A1) ,partial - CSB-YP859521HU CSB-EP859521HU CSB-BP859521HU CSB-MP859521HU from Cusabio
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Recombinant Homo sapiens (Human) Collagen alpha-1(XII) chain - CSB-EP859521HU from Cusabio
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Collagen XII alpha1 Protein - NBP1-88062PEP from Novus Biologicals
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COL12A1 Peptide, Human - M34GP03435H from Creative Peptides
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COL12A1 Recombinant Protein (OPCA03220) - OPCA03220 from Aviva Systems Biology
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Human COL12A1 protein - orb358450 from Biorbyt
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Recombinant Human Collagen alpha-1(XII) chain(COL12A1) ,partial - AP73839 from Signalway Antibody
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Collagen XII alpha1 Recombinant Protein Antigen - NBP2-57420PEP from Novus Biologicals
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Collagen alpha-1 (XII) chain (COL12A1), Recombinant Protein - MBS9423419 from MyBioSource
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Collagen alpha-1(XII) chain, Recombinant Protein - MBS1420623 from MyBioSource
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