XRCC2

Gene Symbol XRCC2
Entrez Gene 7516
Alt Symbol -
Species Human
Gene Type protein-coding
Description X-ray repair complementing defective repair in Chinese hamster cells 2
Other Description DNA repair protein XRCC2|X-ray repair cross-complementing protein 2
Swissprots B2R925 O43543
Accessions AAC05802 AAM55241 CAA76597 EAW53967 EAW53968 O43543 AF035587 AAC05369 AK313607 BAG36372 BC042137 AAH42137 CR749256 CAH18112 Y08837 CAA70065 NM_005431 NP_005422
Function Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the Rad21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2- dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. {ECO:0000269|PubMed:11751635, ECO:0000269|PubMed:11834724, ECO:0000269|PubMed:21276791, ECO:0000269|PubMed:23149936}.
Subcellular Location Nucleus {ECO:0000269|PubMed:21276791}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:21276791}.
Top Pathways Homologous recombination

XRCC2 (F-4) - sc-365854 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
XRCC2 (F-4): sc-365854. Western blot analysis of XRCC2 expression in non-transfected (A) and human XRCC2 transfected (B) whole cell lysates.

XRCC2 (E-17) - sc-5896 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
XRCC2 (E-17): sc-5896. Western blot analysis of XRCC2 expression in Jurkat whole cell lysate (A) and K-562 (B) and Jurkat (C) nuclear extracts.

XRCC2 (N-20) - sc-5895 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
XRCC2 (N-20): sc-5895. Western blot analysis of XRCC2 expression in HeLa nuclear extract.

XRCC2 (1G4/1) - sc-53469 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

XRCC2 (7B7/3) - sc-53470 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

XRCC2 (3C190) - sc-73278 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

Anti-XRCC2 antibody - ab97316 from Abcam

Prices $376.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-XRCC2 antibody (ab97316) at 1/1000 dilution + Raji whole cell lysate at 30 µg

Anti-XRCC2 antibody - ab180752 from Abcam

Prices $378.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence analysis of MCF7 cells using ab180752. Blue DAPI for nuclear staining.

Anti-XRCC2 antibody - ab58466 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Ab58466, at 1/50 dilution, staining paraffin embedded human lung carcinoma tissue by Immunohistochemistry in the absence (left image) or presence (right image) of the immunising peptide.

Anti-XRCC2 antibody - ab137373 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-XRCC2 antibody (ab137373) at 1/500 dilutionLane 1 : MOLT4 whole cell lysateLane 2 : Raji whole cell lysateLysates/proteins at 30 µg per lane.

Anti-XRCC2 antibody - ab172057 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-XRCC2 antibody (ab172057) at 1 µg/mlLane 1 : XRCC2 transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 15 µl per lane.

Anti-XRCC2 antibody [EPR5149] - ab124900 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5149
All lanes : Anti-XRCC2 antibody [EPR5149] (ab124900) at 1/10000 dilutionLane 1 : Human testis lysateLane 2 : HeLa lysateLane 3 : SW480 lysateLane 4 : SH-SY5Y lysateLane 5 : Caco 2 lysateLane 6 : Human kidney lysateLysates/proteins at 10 µg per lane.SecondaryGoat anti-Rabbit HRP at 1/2000 dilution

Anti-XRCC2 antibody, prediluted - ab15253 from Abcam

Prices $376.00
Sizes 7 ml
Host Rabbit
Clonality Polyclonal
ab15253 staining XRCC2 in Human testis by Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Anti-XRCC2 antibody [XRCC2 1G4/1] - ab20253 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone XRCC2 1G4/1

Anti-XRCC2 Antibody - LS-C11103 from LifeSpan Bioscience

Prices $355.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-XRCC2 Antibody - LS-C90774 from LifeSpan Bioscience

Prices $575.00
Sizes 500 µl
Host Rabbit
Clonality Polyclonal

Anti-XRCC2 Antibody (N-Terminus) - LS-C50666 from LifeSpan Bioscience

Prices $440.00
Sizes 250 µl
Host Rabbit
Clonality Polyclonal
Human testis stained with Anti-XRCC2 antibody

Anti-XRCC2 Antibody (N-Terminus) - LS-C95916 from LifeSpan Bioscience

Prices $415.00, $690.00
Sizes 500 µl, 1 ml
Host Rabbit
Clonality Polyclonal
Formalin-fixed, paraffin-embedded human testis stained with XRCC2 antibody LS-C95916.

Anti-XRCC2 Antibody (N-Terminus) - LS-C189289 from LifeSpan Bioscience

Prices $425.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-XRCC2 Antibody (aa211-260) - LS-C118640 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded human lung carcinoma, using XRCC2 Antibody. The picture on the right is treated with the synthesized peptide.

Anti-XRCC2 Antibody (aa1-30, AP) - LS-C207875 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-XRCC2 Antibody (aa1-30, APC) - LS-C207876 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-XRCC2 Antibody (aa1-30, Biotin) - LS-C207877 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-XRCC2 Antibody (aa1-30, FITC) - LS-C209074 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-XRCC2 Antibody (aa1-30, Azide-free, HRP) - LS-C209075 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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