PDGFA
| Gene Symbol | PDGFA |
|---|---|
| Entrez Gene | 5154 |
| Alt Symbol | PDGF-A, PDGF1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | platelet-derived growth factor alpha polypeptide |
| Other Description | PDGF A-chain|PDGF subunit A|PDGF-1|platelet-derived growth factor A chain|platelet-derived growth factor alpha chain|platelet-derived growth factor alpha isoform 2 preproprotein|platelet-derived growth factor subunit A |
| Swissprots | B5BU73 P04085 |
| Accessions | AAA60045 AAA60046 AAA60047 AAB26566 AAD13863 AAD13864 AAK29998 AAN76486 CAA02288 CAA02293 CAA02624 CAB59509 CAH23423 CAJ32894 CAJ32906 CAL32765 CBH30541 EAW87160 EAW87161 EAW87162 P04085 A09204 CAA00830 AB451309 BAG70123 AB451439 BAG70253 AK292217 BAF84906 AU118732 BC109246 AAI09247 BC141593 AAI41594 BC146594 AAI46595 BE336646 BQ001096 BQ002008 X03795 CAA27421 X06374 CAA29677 XM_011515415 XP_011513717 XM_011515416 XP_011513718 XM_011515417 XP_011513719 XM_011515418 XP_011513720 XM_011515419 XP_011513721 NM_002607 NP_002598 NM_033023 NP_148983 |
| Function | Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal lung alveolar septum formation during embryogenesis, normal development of the gastrointestinal tract, normal development of Leydig cells and spermatogenesis. Required for normal oligodendrocyte development and normal myelination in the spinal cord and cerebellum. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFB (By similarity). {ECO:0000250}. |
| Subcellular Location | Secreted. Note=Released by platelets upon wounding. |
| Top Pathways | MicroRNAs in cancer, PI3K-Akt signaling pathway, Choline metabolism in cancer, Cytokine-cytokine receptor interaction, Rap1 signaling pathway |
PDGF-A CRISPR/Cas9 KO Plasmid (h) - sc-400711 from Santa Cruz Biotechnology
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PDGF-A HDR Plasmid (h) - sc-400711-HDR from Santa Cruz Biotechnology
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PDGF-A Double Nickase Plasmid (h) - sc-400711-NIC from Santa Cruz Biotechnology
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PDGF-A Double Nickase Plasmid (h2) - sc-400711-NIC-2 from Santa Cruz Biotechnology
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PDGF-A CRISPR Activation Plasmid (h) - sc-400711-ACT from Santa Cruz Biotechnology
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PDGF-A CRISPR Activation Plasmid (h2) - sc-400711-ACT-2 from Santa Cruz Biotechnology
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PDGF-A Lentiviral Activation Particles (h) - sc-400711-LAC from Santa Cruz Biotechnology
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PDGF-A Lentiviral Activation Particles (h2) - sc-400711-LAC-2 from Santa Cruz Biotechnology
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PDGF-A siRNA (h) - sc-39703 from Santa Cruz Biotechnology
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PDGF-A shRNA Plasmid (h) - sc-39703-SH from Santa Cruz Biotechnology
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PDGF-A shRNA (h) Lentiviral Particles - sc-39703-V from Santa Cruz Biotechnology
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PDGFA RNAi - H00005154-R03 from Novus Biologicals
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PDGFA RNAi - H00005154-R01 from Novus Biologicals
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MISSION® esiRNA - EHU105131 from Sigma-Aldrich
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MISSION® esiRNA - EHU118001 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN16550 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16550 from Sigma-Aldrich
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PDGFA siRNA (Human) - CRH3434 from Cohesion Biosciences
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PDGFA RNAi - H00005154-R02 from Novus Biologicals
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PDGFA RNAi - H00005154-R04 from Novus Biologicals
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shRNA set against Human PDGFA (NM_002607.5) - SHH372636 from Creative biogene
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PDGFA shRNA Plasmid (Human) - CHH3434 from Cohesion Biosciences
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