| Gene Symbol |
JAGN1
|
| Entrez Gene |
84522
|
| Alt Symbol |
GL009, SCN6
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
jagunal homolog 1 (Drosophila)
|
| Other Description |
protein jagunal homolog 1
|
| Swissprots |
Q96SW1 Q8NCF6 Q8N5M9
|
| Accessions |
CAF85930 EAW64015 Q8N5M9 AF212230 AAK14916 AK027508 BAB55163 AK074760 BAC11188 AK225756 BC008507 BC032101 AAH32101 BP262753 DQ892281 ABM83207 DQ895481 ABM86407 NM_032492 NP_115881
|
| Function |
Endoplasmic reticulum transmembrane protein involved in vesicle-mediated transport, which is required for neutrophil function. Required for vesicle-mediated transport; it is however unclear whether it is involved in early secretory pathway or intracellular protein transport. Acts as a regulator of neutrophil function, probably via its role in vesicle-mediated transport: required for defense against fungal pathogens and for granulocyte colony-stimulating factor (GM-CSF) signaling pathway; possibly by regulating glycosylation and/or targeting of proteins contributing to the viability and migration of neutrophils. {ECO:0000269|PubMed:25129144, ECO:0000305}.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000269|PubMed:25129144}; Multi-pass membrane protein {ECO:0000255}.
|
| Tissue Specificity |
Ubiquitously expressed. {ECO:0000269|PubMed:25129144}.
|