Gene Symbol | JAGN1 |
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Entrez Gene | 84522 |
Alt Symbol | GL009, SCN6 |
Species | Human |
Gene Type | protein-coding |
Description | jagunal homolog 1 (Drosophila) |
Other Description | protein jagunal homolog 1 |
Swissprots | Q96SW1 Q8NCF6 Q8N5M9 |
Accessions | CAF85930 EAW64015 Q8N5M9 AF212230 AAK14916 AK027508 BAB55163 AK074760 BAC11188 AK225756 BC008507 BC032101 AAH32101 BP262753 DQ892281 ABM83207 DQ895481 ABM86407 NM_032492 NP_115881 |
Function | Endoplasmic reticulum transmembrane protein involved in vesicle-mediated transport, which is required for neutrophil function. Required for vesicle-mediated transport; it is however unclear whether it is involved in early secretory pathway or intracellular protein transport. Acts as a regulator of neutrophil function, probably via its role in vesicle-mediated transport: required for defense against fungal pathogens and for granulocyte colony-stimulating factor (GM-CSF) signaling pathway; possibly by regulating glycosylation and/or targeting of proteins contributing to the viability and migration of neutrophils. {ECO:0000269|PubMed:25129144, ECO:0000305}. |
Subcellular Location | Endoplasmic reticulum membrane {ECO:0000269|PubMed:25129144}; Multi-pass membrane protein {ECO:0000255}. |
Tissue Specificity | Ubiquitously expressed. {ECO:0000269|PubMed:25129144}. |
JAGN1 CRISPR/Cas9 KO Plasmid (h) - sc-407209 from Santa Cruz Biotechnology
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JAGN1 HDR Plasmid (h) - sc-407209-HDR from Santa Cruz Biotechnology
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JAGN1 Double Nickase Plasmid (h) - sc-407209-NIC from Santa Cruz Biotechnology
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JAGN1 Double Nickase Plasmid (h2) - sc-407209-NIC-2 from Santa Cruz Biotechnology
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JAGN1 CRISPR Activation Plasmid (h) - sc-407209-ACT from Santa Cruz Biotechnology
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JAGN1 CRISPR Activation Plasmid (h2) - sc-407209-ACT-2 from Santa Cruz Biotechnology
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JAGN1 Lentiviral Activation Particles (h) - sc-407209-LAC from Santa Cruz Biotechnology
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JAGN1 Lentiviral Activation Particles (h2) - sc-407209-LAC-2 from Santa Cruz Biotechnology
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JAGN1 siRNA (h) - sc-78313 from Santa Cruz Biotechnology
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JAGN1 shRNA Plasmid (h) - sc-78313-SH from Santa Cruz Biotechnology
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JAGN1 shRNA (h) Lentiviral Particles - sc-78313-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU096601 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN10854 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10854 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR07624 from Sigma-Aldrich
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JAGN1 siRNA (Human) - CRJ3507 from Cohesion Biosciences
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JAGN1, siRNA - MBS8224756 from MyBioSource
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shRNA set against Human JAGN1 (NM_032492.3) - SHH321899 from Creative biogene
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Human JAGN1 siRNA - orb274008 from Biorbyt
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JAGN1 shRNA Plasmid (Human) - CHJ3507 from Cohesion Biosciences
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JAGN1 miRNA 3'UTR clone - MiUTR3H-15160 from Creative biogene
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