| Gene Symbol | ACOT8 |
|---|---|
| Entrez Gene | 10005 |
| Alt Symbol | HNAACTE, PTE-1, PTE-2, PTE1, PTE2, hACTE-III, hTE |
| Species | Human |
| Gene Type | protein-coding |
| Description | acyl-CoA thioesterase 8 |
| Other Description | HIV-Nef associated acyl-CoA thioesterase|acyl-coenzyme A thioesterase 8|choloyl-CoA hydrolase|choloyl-coenzyme A thioesterase|long-chain fatty-acyl-CoA hydrolase|palmitoyl-CoA hydrolase|peroxisomal acyl-CoA thioesterase 1|peroxisomal acyl-coenzyme A thioester hydrolase 1|peroxisomal long-chain acyl-CoA thioesterase 1|thioesterase II|thioesterase III |
| Swissprots | O15261 O14734 Q17RX4 |
| Accessions | EAW75794 EAW75795 EAW75796 EAW75797 EAW75798 O14734 AF014404 AAB71665 AF124264 AAD27616 AK056668 BAG51780 AK126206 AK292494 BAF85183 AK296973 BAG59516 AK298783 BAG60922 BC117155 AAI17156 BC117157 AAI17158 BI911038 BM986979 CR541771 CAG46570 CR541778 CAG46577 DB470803 HQ258192 ADR82946 X86032 CAA60024 XM_005260239 XP_005260296 XM_005260240 XP_005260297 XM_011528480 XP_011526782 XR_244130 NM_005469 NP_005460 NM_183385 NM_183386 |
| Function | Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. May mediate Nef-induced down-regulation of CD4. Major thioesterase in peroxisomes. Competes with BAAT (Bile acid CoA: amino acid N- acyltransferase) for bile acid-CoA substrate (such as chenodeoxycholoyl-CoA). Shows a preference for medium-length fatty acyl-CoAs (By similarity). May be involved in the metabolic regulation of peroxisome proliferation. {ECO:0000250, ECO:0000269|PubMed:15194431}. |
| Subcellular Location | Peroxisome. |
| Tissue Specificity | Detected in a T-cell line (at protein level). Ubiquitous. {ECO:0000269|PubMed:9299485}. |
| Top Pathways | Primary bile acid biosynthesis, Peroxisome |