ACOT8

Gene Symbol ACOT8
Entrez Gene 10005
Alt Symbol HNAACTE, PTE-1, PTE-2, PTE1, PTE2, hACTE-III, hTE
Species Human
Gene Type protein-coding
Description acyl-CoA thioesterase 8
Other Description HIV-Nef associated acyl-CoA thioesterase|acyl-coenzyme A thioesterase 8|choloyl-CoA hydrolase|choloyl-coenzyme A thioesterase|long-chain fatty-acyl-CoA hydrolase|palmitoyl-CoA hydrolase|peroxisomal acyl-CoA thioesterase 1|peroxisomal acyl-coenzyme A thioester hydrolase 1|peroxisomal long-chain acyl-CoA thioesterase 1|thioesterase II|thioesterase III
Swissprots O15261 O14734 Q17RX4
Accessions EAW75794 EAW75795 EAW75796 EAW75797 EAW75798 O14734 AF014404 AAB71665 AF124264 AAD27616 AK056668 BAG51780 AK126206 AK292494 BAF85183 AK296973 BAG59516 AK298783 BAG60922 BC117155 AAI17156 BC117157 AAI17158 BI911038 BM986979 CR541771 CAG46570 CR541778 CAG46577 DB470803 HQ258192 ADR82946 X86032 CAA60024 XM_005260239 XP_005260296 XM_005260240 XP_005260297 XM_011528480 XP_011526782 XR_244130 NM_005469 NP_005460 NM_183385 NM_183386
Function Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. May mediate Nef-induced down-regulation of CD4. Major thioesterase in peroxisomes. Competes with BAAT (Bile acid CoA: amino acid N- acyltransferase) for bile acid-CoA substrate (such as chenodeoxycholoyl-CoA). Shows a preference for medium-length fatty acyl-CoAs (By similarity). May be involved in the metabolic regulation of peroxisome proliferation. {ECO:0000250, ECO:0000269|PubMed:15194431}.
Subcellular Location Peroxisome.
Tissue Specificity Detected in a T-cell line (at protein level). Ubiquitous. {ECO:0000269|PubMed:9299485}.
Top Pathways Primary bile acid biosynthesis, Peroxisome

ACOT8 CRISPR/Cas9 KO Plasmid (h) - sc-407262 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ACOT8 HDR Plasmid (h) - sc-407262-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ACOT8 Double Nickase Plasmid (h) - sc-407262-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ACOT8 Double Nickase Plasmid (h2) - sc-407262-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ACOT8 CRISPR Activation Plasmid (h) - sc-407262-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ACOT8 CRISPR Activation Plasmid (h2) - sc-407262-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ACOT8 Lentiviral Activation Particles (h) - sc-407262-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ACOT8 Lentiviral Activation Particles (h2) - sc-407262-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ACOT8 siRNA (h) - sc-41058 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ACOT8 shRNA Plasmid (h) - sc-41058-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ACOT8 shRNA (h) Lentiviral Particles - sc-41058-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU074241 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN2732 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2732 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

ACOT8 siRNA (Human) - CRH6733 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ACOT8 - MBS8236515 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human ACOT8 (NM_005469.3) - SHH230478 from Creative biogene

Category siRNA
Species Reactivities Human

ACOT8 shRNA Plasmid (Human) - CHH6733 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

ACOT8 miRNA 3'UTR clone - MiUTR3H-09763 from Creative biogene

Species Reactivities Human
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