Gene Symbol | Ppp3r1 |
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Entrez Gene | 19058 |
Alt Symbol | CaNB1, Cnb1, MCIP1 |
Species | Mouse |
Gene Type | protein-coding |
Description | protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I) |
Other Description | PP2B beta 1|calcineurin subunit B type 1|protein phosphatase 2B regulatory subunit 1|protein phosphatase 3 regulatory subunit B alpha |
Swissprots | Q63810 Q3V067 Q5F225 |
Accessions | EDL40683 Q63810 AK133403 BAE21637 AK145541 BAE26495 AK160423 AK160938 BAE36102 AK163241 BAE37251 BC002267 BY137249 S43864 AAB23171 NM_024459 NP_077779 |
Function | Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity. |
Subcellular Location | Cytoplasm, cytosol {ECO:0000269|PubMed:20639889}. Cell membrane {ECO:0000269|PubMed:20639889}. Cell membrane, sarcolemma {ECO:0000269|PubMed:20639889}. Note=Translocates from the cytosol to the sarcolemma in a CIB1-dependent manner during cardiomyocytes hypertrophy. |
Tissue Specificity | Brain specific. |
Top Pathways | Glucagon signaling pathway, Tuberculosis, Glutamatergic synapse, Amphetamine addiction, Oxytocin signaling pathway |
PP2B-B1 CRISPR/Cas9 KO Plasmid (m) - sc-422386 from Santa Cruz Biotechnology
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PP2B-B1 HDR Plasmid (m) - sc-422386-HDR from Santa Cruz Biotechnology
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PP2B-B1 Double Nickase Plasmid (m) - sc-422386-NIC from Santa Cruz Biotechnology
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PP2B-B1 Double Nickase Plasmid (m2) - sc-422386-NIC-2 from Santa Cruz Biotechnology
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PP2B-B1 CRISPR Activation Plasmid (m) - sc-422386-ACT from Santa Cruz Biotechnology
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PP2B-B1 CRISPR Activation Plasmid (m2) - sc-422386-ACT-2 from Santa Cruz Biotechnology
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PP2B-B1 Lentiviral Activation Particles (m) - sc-422386-LAC from Santa Cruz Biotechnology
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PP2B-B1 Lentiviral Activation Particles (m2) - sc-422386-LAC-2 from Santa Cruz Biotechnology
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PP2B-B1 siRNA (m) - sc-39200 from Santa Cruz Biotechnology
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PP2B-B1 shRNA Plasmid (m) - sc-39200-SH from Santa Cruz Biotechnology
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PP2B-B1 shRNA (m) Lentiviral Particles - sc-39200-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU073261 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN39208 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND39208 from Sigma-Aldrich
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PPP3R1 siRNA (Mouse) - CRM3204 from Cohesion Biosciences
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shRNA set against Mouse PPP3R1 (NM_024459.2) - SHH381572 from Creative biogene
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shRNA set against Mouse Ppp3r1(NM_024459.2) - SHR135632 from Creative biogene
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Mouse PPP3R1 siRNA - orb282680 from Biorbyt
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PPP3R1 shRNA Plasmid (Mouse) - CHM3204 from Cohesion Biosciences
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PPP3R1 miRNA 3'UTR clone - MiUTR1M-09525 from Creative biogene
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