| Gene Symbol |
Nampt
|
| Entrez Gene |
59027
|
| Alt Symbol |
1110035O14Rik, AI314458, AI480535, NAmPRTase, Pbef, Pbef1, Visfatin
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
nicotinamide phosphoribosyltransferase
|
| Other Description |
pre-B-cell colony-enhancing factor 1 homolog
|
| Swissprots |
Q99KQ4 Q8C3B5 Q9JKM0
|
| Accessions |
EDL36889 Q99KQ4 AF234625 AAF43208 AK004117 AK086415 BAC39664 AK153926 AK166270 BAE38671 AY679720 AAT72933 BC004059 AAH04059 BC018358 AAH18358 BY068469 CV561474 NM_021524 NP_067499
|
| Function |
The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma (By similarity). Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-ARNTL/BMAL1 heterodimer from NAD- dependent SIRT1-mediated suppression. {ECO:0000250|UniProtKB:P43490, ECO:0000269|PubMed:12555668, ECO:0000269|PubMed:15381699, ECO:0000269|PubMed:19286518, ECO:0000269|PubMed:19299583}.
|
| Subcellular Location |
Nucleus {ECO:0000250|UniProtKB:P43490}. Cytoplasm {ECO:0000269|PubMed:12555668}. Secreted {ECO:0000250|UniProtKB:P43490}. Note=Under non-inflammatory conditions, visfatin predominantly exhibits a granular pattern within the nucleus. Secreted by endothelial cells upon IL-1beta stimulation. Abundantly secreted in milk, reaching 100-fold higher concentrations compared to maternal serum. {ECO:0000250|UniProtKB:P43490}.
|
| Tissue Specificity |
Ubiquitously expressed in lymphoid and non- lymphoid tissues. {ECO:0000269|PubMed:12555668}.
|
| Top Pathways |
Nicotinate and nicotinamide metabolism
|