| Gene Symbol | TLE3 |
|---|---|
| Entrez Gene | 7090 |
| Alt Symbol | ESG, ESG3, GRG3, HsT18976 |
| Species | Human |
| Gene Type | protein-coding |
| Description | transducin-like enhancer of split 3 |
| Other Description | enhancer of split groucho 3|enhancer of split groucho-like protein 3|transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)|transducin-like enhancer of split 3, homolog of Drosophila E(sp1)|transducin-like enhancer protein 3 |
| Swissprots | Q8IVV6 F8W964 Q04726 E9PD64 Q8WVR2 Q9HCM5 Q6PI57 B4DPT0 |
| Accessions | EAW77848 EAW77849 EAW77850 EAW77851 Q04726 AB046767 BAB13373 AB209672 BAD92909 AK000083 AK001258 BAG50879 AK096779 BAG53364 AK298482 BAG60692 AK304459 BAG65275 AK315058 AY566265 AAT72913 AY583459 AAS90945 AY583460 AAS90946 BC012004 BC015421 BC015729 BC041831 AAH41831 BC043247 AAH43247 BM676381 BP373048 M99438 AAA61194 XM_005254622 XP_005254679 XM_005254623 XP_005254680 XM_005254625 XP_005254682 XM_005254628 XP_005254685 XM_005254633 XP_005254690 XM_006720665 XP_006720728 XM_011521976 XP_011520278 XM_011521977 XP_011520279 XM_011521978 XP_011520280 XM_011521979 XP_011520281 XM_011521980 XP_011520282 XM_011521981 XP_011520283 XM_011521982 XP_011520284 XM_011521983 XP_011520285 NM_001105192 NP_001098662 NM_001282979 NP_001269908 NM_001282980 NP_001269909 NM_001282981 NP_001269910 NM_001282982 NP_001269911 NM_005078 NP_005069 NM_020908 NP_065959 |
| Function | Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity). {ECO:0000250}. |
| Subcellular Location | Nucleus. |
| Tissue Specificity | Placenta and lung. |
TLE3 CRISPR/Cas9 KO Plasmid (h) - sc-400386 from Santa Cruz Biotechnology
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TLE3 HDR Plasmid (h) - sc-400386-HDR from Santa Cruz Biotechnology
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TLE3 Double Nickase Plasmid (h) - sc-400386-NIC from Santa Cruz Biotechnology
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TLE3 Double Nickase Plasmid (h2) - sc-400386-NIC-2 from Santa Cruz Biotechnology
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TLE3 CRISPR Activation Plasmid (h) - sc-400386-ACT from Santa Cruz Biotechnology
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TLE3 CRISPR Activation Plasmid (h2) - sc-400386-ACT-2 from Santa Cruz Biotechnology
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TLE3 Lentiviral Activation Particles (h) - sc-400386-LAC from Santa Cruz Biotechnology
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TLE3 Lentiviral Activation Particles (h2) - sc-400386-LAC-2 from Santa Cruz Biotechnology
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TLE3 siRNA (h) - sc-36683 from Santa Cruz Biotechnology
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TLE3 shRNA Plasmid (h) - sc-36683-SH from Santa Cruz Biotechnology
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TLE3 shRNA (h) Lentiviral Particles - sc-36683-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN21391 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21391 from Sigma-Aldrich
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TLE3 siRNA (Human) - CRH4857 from Cohesion Biosciences
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TLE3 - MBS8240930 from MyBioSource
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TLE3 CRISPR/Cas9 KO Plasmid (h2) - sc-400386-KO-2 from Santa Cruz Biotechnology
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TLE3 HDR Plasmid (h2) - sc-400386-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human TLE3 (NM_005078.2) - SHH427816 from Creative biogene
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shRNA set against Human TLE3(NM_005078.2) - SHG210547 from Creative biogene
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TLE3 shRNA Plasmid (Human) - CHH4857 from Cohesion Biosciences
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TLE3 miRNA 3'UTR clone - MiUTR1H-10428 from Creative biogene
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TLE3 miRNA 3'UTR clone - MiUTR3H-03183 from Creative biogene
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TLE3 miRNA 3'UTR clone - MiUTR3H-03185 from Creative biogene
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