| Gene Symbol | NPSR1 |
|---|---|
| Entrez Gene | 387129 |
| Alt Symbol | ASRT2, GPR154, GPRA, NPSR, PGR14, VRR1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | neuropeptide S receptor 1 |
| Other Description | G-protein coupled receptor 154|G-protein coupled receptor PGR14|G-protein coupled receptor for asthma susceptibility|neuropeptide S receptor|vasopressin receptor-related receptor 1 |
| Swissprots | Q6JSL6 Q56H77 Q56H76 Q6W5P3 Q6JSL8 A2RTZ4 Q6ZMB8 Q6JSL4 Q6W5P4 Q2XP58 Q56H78 Q6JSL5 Q6JSL7 |
| Accessions | ABB72550 EAL24469 EAL24470 EAW94034 EAW94035 EAW94036 EAW94037 Q6W5P4 AK124929 AK172847 BAD18811 AY255536 AAO85048 AY310326 AAQ76966 AY310327 AAQ76967 AY310328 AAQ76968 AY310329 AAQ76969 AY310330 AAQ76970 AY310331 AAQ76971 AY310332 AAQ76972 AY956446 AAX63744 AY956447 AAX63745 AY956448 AAX63746 BC132693 AAI32694 BC132695 AAI32696 BC144380 AAI44381 HQ258213 ADR82967 NM_001300933 NP_001287862 NM_001300934 NP_001287863 NM_001300935 NP_001287864 NM_207172 NP_997055 NM_207173 NP_997056 |
| Function | G-protein coupled receptor for neuropeptide S (NPS) (PubMed:16790440). Promotes mobilization of intracellular Ca(2+) stores (PubMed:16790440). Inhibits cell growth in response to NPS binding (PubMed:15947423). Involved in pathogenesis of asthma and other IgE-mediated diseases. {ECO:0000269|PubMed:15312648, ECO:0000269|PubMed:15947423, ECO:0000269|PubMed:16790440}. |
| Subcellular Location | Isoform 7: Cytoplasm {ECO:0000269|PubMed:15947423}. |
| Tissue Specificity | Isoform 4 is ubiquitous; it is detected in glandular epithelia of bronchus, stomach, small intestine, colon, uterus, esophagus, spleen, kidney, pancreas, prostate and breast. Isoform 1 is detected in uterus, colon and prostate, and in the smooth muscle cell layer in bronchial and arterial walls (at protein level) (PubMed:15947423). Isoform 1 is predominantly expressed in smooth muscle. Isoform 4 is predominantly expressed in epithelial cells. In bronchial biopsies, it is expressed in smooth muscle cells of asthma patients, but not in control patients; whereas in epithelial cells, its expression is consistently stronger in asthma patients. {ECO:0000269|PubMed:15073379, ECO:0000269|PubMed:15947423}. |