Gene Symbol | TPK1 |
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Entrez Gene | 27010 |
Alt Symbol | HTPK1, PP20, THMD5 |
Species | Human |
Gene Type | protein-coding |
Description | thiamin pyrophosphokinase 1 |
Other Description | placental protein 20|thiamine diphosphokinase|thiamine kinase |
Swissprots | Q9H602 I6L9B8 A8K0T7 Q6NUR5 Q9H3S4 D3DWG0 |
Accessions | AAS00370 EAL24415 EAW80091 EAW80092 Q9H3S4 AB028138 BAB20326 AF297710 AAK01351 AK021810 AK026374 BAB15465 AK091736 BAG52408 AK128661 BAC87556 AK130640 AK289652 BAF82341 AK308693 AY206415 AAO38775 BC014552 BC040555 AAH40555 BC068460 AAH68460 BI770816 BX446289 CR749248 CAH18104 DA135998 XM_005249970 XP_005250027 XM_006715925 XP_006715988 XM_011516031 XP_011514333 XM_011516032 XP_011514334 XM_011516033 XP_011514335 XM_011516034 XP_011514336 XM_011516035 XP_011514337 XM_011516036 XP_011514338 XM_011516037 XP_011514339 XM_011516038 XP_011514340 XM_011516039 XP_011514341 XM_011516040 XP_011514342 XM_011516041 XP_011514343 XM_011516042 XP_011514344 XM_011516043 XP_011514345 XM_011516044 XP_011514346 XM_011516045 XP_011514347 XM_011516046 XP_011514348 XM_011516047 XP_011514349 XM_011516048 XP_011514350 XM_011516049 XP_011514351 XM_011516050 XP_011514352 XR_927446 XR_927448 XR_927450 XR_927451 XR_927453 NM_001042482 NP_001035947 NM_022445 NP_071890 |
Function | Catalyzes the phosphorylation of thiamine to thiamine pyrophosphate. Can also catalyze the phosphorylation of pyrithiamine to pyrithiamine pyrophosphate. {ECO:0000269|PubMed:11342111}. |
Tissue Specificity | Detected in heart, kidney, testis, small intestine and peripheral blood leukocytes, and at very low levels in a variety of tissues. {ECO:0000269|PubMed:11342111, ECO:0000269|PubMed:11342117}. |
Top Pathways | Thiamine metabolism |
TPK1 CRISPR/Cas9 KO Plasmid (h) - sc-411944 from Santa Cruz Biotechnology
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TPK1 HDR Plasmid (h) - sc-411944-HDR from Santa Cruz Biotechnology
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TPK1 Double Nickase Plasmid (h) - sc-411944-NIC from Santa Cruz Biotechnology
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TPK1 Double Nickase Plasmid (h2) - sc-411944-NIC-2 from Santa Cruz Biotechnology
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TPK1 CRISPR Activation Plasmid (h) - sc-411944-ACT from Santa Cruz Biotechnology
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TPK1 CRISPR Activation Plasmid (h2) - sc-411944-ACT-2 from Santa Cruz Biotechnology
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TPK1 Lentiviral Activation Particles (h) - sc-411944-LAC from Santa Cruz Biotechnology
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TPK1 Lentiviral Activation Particles (h2) - sc-411944-LAC-2 from Santa Cruz Biotechnology
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TPK1 siRNA (h) - sc-89540 from Santa Cruz Biotechnology
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TPK1 shRNA Plasmid (h) - sc-89540-SH from Santa Cruz Biotechnology
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TPK1 shRNA (h) Lentiviral Particles - sc-89540-V from Santa Cruz Biotechnology
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TPK1 RNAi - H00027010-R02 from Novus Biologicals
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MISSION® esiRNA - EHU057781 from Sigma-Aldrich
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MISSION® siRNA - SIHK2321 from Sigma-Aldrich
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MISSION® siRNA - SIHK2322 from Sigma-Aldrich
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MISSION® siRNA - SIHK2318 from Sigma-Aldrich
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MISSION® siRNA - SIHK2320 from Sigma-Aldrich
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MISSION® siRNA - SIHK2319 from Sigma-Aldrich
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MISSION® siRNA - SIHK2323 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN21867 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21867 from Sigma-Aldrich
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TPK1 siRNA (Human) - CRH8920 from Cohesion Biosciences
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TPK1 - MBS8236211 from MyBioSource
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shRNA set against Human TPK1 (NM_022445.3) - SHH433304 from Creative biogene
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shRNA set against Human TPK1(NM_001042482.1) - SHL089796 from Creative biogene
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