PIP5K1A

Gene Symbol PIP5K1A
Entrez Gene 8394
Alt Symbol -
Species Human
Gene Type protein-coding
Description phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
Other Description 68 kDa type I phosphatidylinositol 4-phosphate 5-kinase alpha|68 kDa type I phosphatidylinositol-4-phosphate 5-kinase alpha|PIP5K1-alpha|PIP5KIalpha|phosphatidylinositol 4-phosphate 5-kinase type I alpha|phosphatidylinositol 4-phosphate 5-kinase type-1 alpha|phosphatidylinositol-4-phosphate 5-kinase type-1 alpha|ptdIns(4)P-5-kinase 1 alpha
Swissprots B4DIN0 Q99754 Q99755 A8K4Q0 Q99756
Accessions EAW53459 EAW53460 EAW53461 Q99755 AF085856 AK291015 BAF83704 AK295691 BAG58542 AK302268 BAG63614 AK309826 BC007833 AAH07833 DA759212 DQ656041 U78575 AAC50910 U78576 AAC50911 U78577 AAC50912 U78578 AAC50913 XM_005245525 XP_005245582 XM_005245526 XP_005245583 XM_005245527 XP_005245584 XM_005245528 XP_005245585 XM_005245529 XP_005245586 XM_005245530 XP_005245587 XM_005245531 XP_005245588 XM_005245532 XP_005245589 XM_006711563 XP_006711626 XM_006711564 XP_006711627 XM_006711567 XP_006711630 XM_006711568 XP_006711631 XM_011510042 XP_011508344 XM_011510043 XP_011508345 XM_011510044 XP_011508346 XM_011510045 XP_011508347 XM_011510046 XP_011508348 XM_011510047 XP_011508349 XM_011510048 XP_011508350 XM_011510049 XP_011508351 XM_011510050 XP_011508352 NM_001135636 NP_001129108 NM_001135637 NP_001129109 NM_001135638 NP_001129110 NM_003557 NP_003548
Function Catalyzes the phosphorylation of phosphatidylinositol 4- phosphate (PtdIns4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). PtdIns(4,5)P2 is involved in a variety of cellular processes and is the substrate to form phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3), another second messenger. The majority of PtdIns(4,5)P2 is thought to occur via type I phosphatidylinositol 4-phosphate 5-kinases given the abundance of PtdIns4P. Participates in a variety of cellular processes such as actin cytoskeleton organization, cell adhesion, migration and phagocytosis. Required for membrane ruffling formation, actin organization and focal adhesion formation during directional cell migration by controlling integrin-induced translocation of RAC1 to the plasma membrane. Together with PIP5K1C is required for phagocytosis, but they regulate different types of actin remodeling at sequential steps. Promotes particle ingestion by activating WAS that induces Arp2/3 dependent actin pol
Subcellular Location Cell membrane. Cytoplasm {ECO:0000250}. Nucleus speckle. Cell projection, ruffle. Note=Colocalizes with RAC1 at actin-rich membrane ruffles. Localizes to nuclear speckles and associates with TUT1 to regulate polyadenylation of selected mRNAs.
Tissue Specificity Highly expressed in heart, placenta, skeletal muscle, kidney and pancreas. Detected at lower levels in brain, lung and liver.
Top Pathways Fc gamma R-mediated phagocytosis, Endocytosis, Choline metabolism in cancer, Inositol phosphate metabolism, Regulation of actin cytoskeleton

PIP5K1A Antibody - 9693 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell lines using PIP5K1A Antibody.

PIPK I α (B-10) - sc-376634 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PIPK I α (B-10): sc-376634. Western blot analysis of PIPK I α expression in K-562 whole cell lysate.

PIPK I α (F-4) - sc-398687 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PIPK I α (F-4): sc-398687. Western blot analysis of PIPK I α expression in K-562 (A), HeLa (B), NAMALWA (C) and Raji (D) whole cell lysates.

PIPK I α (A-17) - sc-11772 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PIPK I α (A-17): sc-11772. Western blot analysis of PIPK I α expression in K-562 whole cell lysate.

PIPK I α (D-12) - sc-377021 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PIPK I α (D-12): sc-377021. Immunoperoxidase staining of formalin fixed, paraffin-embedded human tonsil tissue showing cytoplasmic staining of squamous epithelial cells.

PIPK I α (E-3) - sc-376195 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PIPK I α (E-3): sc376195. Immunofluorescence staining of methanol-fixed HeLa cells showing nuclear speckle and cytoplasmic localization.

PIPK I α (C-17) - sc-11774 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PIPK I α (C-17): sc-11774. Immunofluorescence staining of methanol-fixed HeLa cells showing nuclear and cytoplasmic staining.

PIPK I α (M-20) - sc-11775 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PIPK I α (M-20): sc-11775. Western blot analysis of PIPK I α expression in non-transfected: sc-117752 (A) and mouse PIPK I α transfected: sc-122588 (B) 293T whole cell lysates.

PIPK I α (N-20) - sc-11771 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PIPK I α (N-20): sc-11771. Western blot analysis of PIPK I α expression in HeLa (A), K-562 (B), THP-1 (C) and SK-N-SH (D) whole cell lysates.

Anti-PIP5K1 alpha antibody - ab122049 from Abcam

Prices $443.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-PIP5K1 alpha antibody (ab122049) at 1/250 dilutionLane 1 : RT-4 cells lysateLane 2 : U-251 MG cells lysateLane 3 : Human plasma lysateLane 4 : Human Liver lysateLane 5 : Human Tonsil lysate

Anti-PIP5K1 alpha antibody - ab5466 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PIP5K1A Antibody (aa19-50) - LS-C101112 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of anti-PIP5K1A antibody in HeLa cell lysate. PIP5K1A (arrow) was detected using purified antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.

Anti-PIP5K1A Antibody (Internal) IHC-plus™ - LS-B10813 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-PIP5K1A antibody IHC staining of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B10813 concentration 5 ug/ml.

Anti-PIP5K1A Antibody (N-Terminus, AP) - LS-C220322 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PIP5K1A Antibody (N-Terminus, APC) - LS-C220327 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PIP5K1A Antibody (N-Terminus, Biotin) - LS-C220328 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PIP5K1A Antibody (N-Terminus, Azide-free, HRP) - LS-C220330 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PIP5K1A Antibody (N-Terminus, FITC) - LS-C220329 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PIP5K1A Antibody (N-Terminus, PE) - LS-C220331 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PIP5K1A Antibody (N-Terminus) - LS-C330580 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PIP5K1A Antibody (aa38-87) - LS-C201758 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of Mouse Lung. Pip5k1a antibody dilution 1.0 ug/ml.

Anti-PIP5K1A Antibody (Internal) - LS-C345578 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of PIP5K1A Antibody with human MCF7 Whole Cell lysate.

PIP5K1 alpha Antibody - NBP1-90358 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: PIP5K1 alpha Antibody [NBP1-90358] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11. Lane 2: Human cell line RT-430

PIP5K1 alpha Antibody - NBP2-19833 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: PIP5K1 alpha Antibody [NBP2-19833] - Sample (30 ug of whole cell lysate) A: A431 B: H1299 C: Hela 7. 5% SDS PAGE gel, diluted at 1:1000.

PIP5K1 alpha Antibody - NBP1-32477 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: PIP5K1 alpha Antibody [NBP1-32477] - (30 ug whole cell lysate) A:293T 7.5% SDS PAGE diluted at 1:1000
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