| Gene Symbol | PIP5K1A |
|---|---|
| Entrez Gene | 8394 |
| Alt Symbol | - |
| Species | Human |
| Gene Type | protein-coding |
| Description | phosphatidylinositol-4-phosphate 5-kinase, type I, alpha |
| Other Description | 68 kDa type I phosphatidylinositol 4-phosphate 5-kinase alpha|68 kDa type I phosphatidylinositol-4-phosphate 5-kinase alpha|PIP5K1-alpha|PIP5KIalpha|phosphatidylinositol 4-phosphate 5-kinase type I alpha|phosphatidylinositol 4-phosphate 5-kinase type-1 alpha|phosphatidylinositol-4-phosphate 5-kinase type-1 alpha|ptdIns(4)P-5-kinase 1 alpha |
| Swissprots | B4DIN0 Q99754 Q99755 A8K4Q0 Q99756 |
| Accessions | EAW53459 EAW53460 EAW53461 Q99755 AF085856 AK291015 BAF83704 AK295691 BAG58542 AK302268 BAG63614 AK309826 BC007833 AAH07833 DA759212 DQ656041 U78575 AAC50910 U78576 AAC50911 U78577 AAC50912 U78578 AAC50913 XM_005245525 XP_005245582 XM_005245526 XP_005245583 XM_005245527 XP_005245584 XM_005245528 XP_005245585 XM_005245529 XP_005245586 XM_005245530 XP_005245587 XM_005245531 XP_005245588 XM_005245532 XP_005245589 XM_006711563 XP_006711626 XM_006711564 XP_006711627 XM_006711567 XP_006711630 XM_006711568 XP_006711631 XM_011510042 XP_011508344 XM_011510043 XP_011508345 XM_011510044 XP_011508346 XM_011510045 XP_011508347 XM_011510046 XP_011508348 XM_011510047 XP_011508349 XM_011510048 XP_011508350 XM_011510049 XP_011508351 XM_011510050 XP_011508352 NM_001135636 NP_001129108 NM_001135637 NP_001129109 NM_001135638 NP_001129110 NM_003557 NP_003548 |
| Function | Catalyzes the phosphorylation of phosphatidylinositol 4- phosphate (PtdIns4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). PtdIns(4,5)P2 is involved in a variety of cellular processes and is the substrate to form phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3), another second messenger. The majority of PtdIns(4,5)P2 is thought to occur via type I phosphatidylinositol 4-phosphate 5-kinases given the abundance of PtdIns4P. Participates in a variety of cellular processes such as actin cytoskeleton organization, cell adhesion, migration and phagocytosis. Required for membrane ruffling formation, actin organization and focal adhesion formation during directional cell migration by controlling integrin-induced translocation of RAC1 to the plasma membrane. Together with PIP5K1C is required for phagocytosis, but they regulate different types of actin remodeling at sequential steps. Promotes particle ingestion by activating WAS that induces Arp2/3 dependent actin pol |
| Subcellular Location | Cell membrane. Cytoplasm {ECO:0000250}. Nucleus speckle. Cell projection, ruffle. Note=Colocalizes with RAC1 at actin-rich membrane ruffles. Localizes to nuclear speckles and associates with TUT1 to regulate polyadenylation of selected mRNAs. |
| Tissue Specificity | Highly expressed in heart, placenta, skeletal muscle, kidney and pancreas. Detected at lower levels in brain, lung and liver. |
| Top Pathways | Fc gamma R-mediated phagocytosis, Endocytosis, Choline metabolism in cancer, Inositol phosphate metabolism, Regulation of actin cytoskeleton |
PIPK I α CRISPR/Cas9 KO Plasmid (h) - sc-403490 from Santa Cruz Biotechnology
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PIPK I α HDR Plasmid (h) - sc-403490-HDR from Santa Cruz Biotechnology
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PIPK I α Double Nickase Plasmid (h) - sc-403490-NIC from Santa Cruz Biotechnology
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PIPK I α Double Nickase Plasmid (h2) - sc-403490-NIC-2 from Santa Cruz Biotechnology
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PIPK I α CRISPR Activation Plasmid (h) - sc-403490-ACT from Santa Cruz Biotechnology
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PIPK I α CRISPR Activation Plasmid (h2) - sc-403490-ACT-2 from Santa Cruz Biotechnology
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PIPK I α Lentiviral Activation Particles (h) - sc-403490-LAC from Santa Cruz Biotechnology
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PIPK I α Lentiviral Activation Particles (h2) - sc-403490-LAC-2 from Santa Cruz Biotechnology
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PIPK I α siRNA (h) - sc-36232 from Santa Cruz Biotechnology
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PIPK I α shRNA Plasmid (h) - sc-36232-SH from Santa Cruz Biotechnology
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PIPK I α shRNA (h) Lentiviral Particles - sc-36232-V from Santa Cruz Biotechnology
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PIP5K1 alpha RNAi - H00008394-R02 from Novus Biologicals
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MISSION® esiRNA - EHU114801 from Sigma-Aldrich
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MISSION® siRNA - SIHK1700 from Sigma-Aldrich
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MISSION® siRNA - SIHK1701 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN16826 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16826 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR10125 from Sigma-Aldrich
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PIP5K1A siRNA (Human) - CRH5500 from Cohesion Biosciences
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PIP5K1A shRNA Plasmid (Human) - CHH5500 from Cohesion Biosciences
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PIP5K1A miRNA 3'UTR clone - MiUTR3H-05831 from Creative biogene
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PIP5K1A miRNA 3'UTR clone - MiUTR3H-05832 from Creative biogene
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PIP5K1A miRNA 3'UTR clone - MiUTR3H-05833 from Creative biogene
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PIP5K1A miRNA 3'UTR clone - MiUTR3H-05834 from Creative biogene
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