| Gene Symbol |
TWSG1
|
| Entrez Gene |
57045
|
| Alt Symbol |
TSG
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
twisted gastrulation BMP signaling modulator 1
|
| Other Description |
twisted gastrulation homolog 1|twisted gastrulation protein homolog 1
|
| Swissprots |
Q96K46 B2RE08 Q9GZX9 Q8NBI7 D3DUH9
|
| Accessions |
EAX01606 EAX01607 Q9GZX9 AF196834 AAG43468 AF294628 AAG10076 AI742025 AJ297391 CAC05581 AK027629 BAB55246 AK075550 BAC11693 AK315751 BAG38105 BC020490 AAH20490 BU632669 DA735800 HQ447098 ADQ31585 XM_011525704 XP_011524006 NM_020648 NP_065699
|
| Function |
May be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Secreted {ECO:0000250}.
|