Gene Symbol | TWSG1 |
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Entrez Gene | 57045 |
Alt Symbol | TSG |
Species | Human |
Gene Type | protein-coding |
Description | twisted gastrulation BMP signaling modulator 1 |
Other Description | twisted gastrulation homolog 1|twisted gastrulation protein homolog 1 |
Swissprots | Q96K46 B2RE08 Q9GZX9 Q8NBI7 D3DUH9 |
Accessions | EAX01606 EAX01607 Q9GZX9 AF196834 AAG43468 AF294628 AAG10076 AI742025 AJ297391 CAC05581 AK027629 BAB55246 AK075550 BAC11693 AK315751 BAG38105 BC020490 AAH20490 BU632669 DA735800 HQ447098 ADQ31585 XM_011525704 XP_011524006 NM_020648 NP_065699 |
Function | May be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development (By similarity). {ECO:0000250}. |
Subcellular Location | Secreted {ECO:0000250}. |
twisted CRISPR/Cas9 KO Plasmid (h) - sc-412752 from Santa Cruz Biotechnology
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twisted HDR Plasmid (h) - sc-412752-HDR from Santa Cruz Biotechnology
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twisted Double Nickase Plasmid (h) - sc-412752-NIC from Santa Cruz Biotechnology
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twisted Double Nickase Plasmid (h2) - sc-412752-NIC-2 from Santa Cruz Biotechnology
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twisted CRISPR Activation Plasmid (h) - sc-412752-ACT from Santa Cruz Biotechnology
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twisted CRISPR Activation Plasmid (h2) - sc-412752-ACT-2 from Santa Cruz Biotechnology
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twisted Lentiviral Activation Particles (h) - sc-412752-LAC from Santa Cruz Biotechnology
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twisted Lentiviral Activation Particles (h2) - sc-412752-LAC-2 from Santa Cruz Biotechnology
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twisted gastrulation siRNA (h) - sc-106651 from Santa Cruz Biotechnology
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twisted gastrulation shRNA Plasmid (h) - sc-106651-SH from Santa Cruz Biotechnology
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twisted gastrulation shRNA (h) Lentiviral Particles - sc-106651-V from Santa Cruz Biotechnology
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TSG RNAi - H00057045-R01 from Novus Biologicals
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MISSION® esiRNA - EHU019731 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN22295 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22295 from Sigma-Aldrich
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TWSG1 siRNA (Human) - CRJ1298 from Cohesion Biosciences
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TWSG1 - MBS8227007 from MyBioSource
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shRNA set against Human TWSG1 (NM_020648.5) - SHH438096 from Creative biogene
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Human TWSG1 siRNA - orb271799 from Biorbyt
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TWSG1 shRNA Plasmid (Human) - CHJ1298 from Cohesion Biosciences
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