| Gene Symbol | MECOM |
|---|---|
| Entrez Gene | 2122 |
| Alt Symbol | AML1-EVI-1, EVI1, MDS1, MDS1-EVI1, PRDM3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | MDS1 and EVI1 complex locus |
| Other Description | AML1-EVI-1 fusion protein|MDS1 and EVI1 complex locus protein EVI1|MDS1 and EVI1 complex locus protein MDS1|ecotropic virus integration site 1 protein homolog|myelodysplasia syndrome-associated protein 1|oncogene EVI1|zinc finger protein Evi1 |
| Swissprots | B7Z8W7 Q13466 Q03112 D3DNP7 A8KA00 Q5HYI1 Q6MZS6 Q13465 Q99917 A1L4F3 Q6FH90 B7ZLQ4 Q16122 B7ZLQ3 Q8NEI5 C9JAK0 |
| Accessions | EAW78549 EAW78550 EAW78552 EAW78553 EAW78554 EAW78555 EAW78556 EAW78557 EAW78558 EAW78559 Q03112 Q13465 AA043944 AF164154 AAF04008 AF164155 AAF04009 AF164156 AAF04010 AF164157 AAF04011 AF487422 AAN39687 AF487423 AAN39688 AF487424 AAN39689 AK025934 AK292865 BAF85554 AK304098 BAH14103 AK308404 AK310509 AL700380 BC012450 BC031019 AAH31019 BC069498 AAH69498 BC130520 AAI30521 BC143951 AAI43952 BC143952 AAI43953 BX484790 BX640908 CAE45952 BX647613 CAI46086 CR541866 CAG46664 CR541886 CAG46684 DC347146 DC348381 EU832138 ACE87488 EU832231 ACE86801 GQ352634 ACU31119 S82592 AAB37456 U43292 AAB05839 U43293 AAB05840 X54989 CAA38735 XM_005247213 XP_005247270 XM_005247214 XP_005247271 XM_005247215 XP_005247272 XM_005247219 XP_005247276 XM_005247220 XP_005247277 XM_005247221 XP_005247278 XM_005247223 XP_005247280 XM_005247224 XP_005247281 XM_005247225 XP_005247282 XM_005247226 XP_005247283 XM_011512546 XP_011510848 XM_011512547 XP_011510849 XM_011512548 XP_011510850 NM_001105077 NP_001098547 NM_001105078 NP_001098548 NM_001163999 NP_001157471 NM_001164000 NP_001157472 NM_001205194 NP_001192123 NM_004991 NP_004982 NM_005241 NP_005232 |
| Function | Functions as a transcriptional regulator binding to DNA sequences in the promoter region of target genes and regulating positively or negatively their expression. Oncogene which plays a role in development, cell proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved in hematopoiesis. {ECO:0000269|PubMed:10856240, ECO:0000269|PubMed:11568182, ECO:0000269|PubMed:15897867, ECO:0000269|PubMed:16462766, ECO:0000269|PubMed:19767769, ECO:0000269|PubMed:9665135}. |
| Subcellular Location | Nucleus. Nucleus speckle. |
| Top Pathways | Chronic myeloid leukemia, MAPK signaling pathway |
Human MECOM cDNA clone(NM_001105077.3) - CDFH011263 from Creative Biomart
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Human MECOM cDNA clone(NM_001163999.1) - CDFH011264 from Creative Biomart
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Human MECOM cDNA clone(NM_001164000.1) - CDFH011265 from Creative Biomart
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Human MECOM cDNA clone(NM_004991.3) - CDFH011266 from Creative Biomart
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Human MECOM ORF Clone(NM_004991.3) - CDCR289367 from Creative Biomart
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Human MECOM ORF Clone(NM_004991.3) - CDCR289368 from Creative Biomart
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Human MECOM ORF Clone(NM_004991.3) - CDCR289369 from Creative Biomart
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Human MECOM ORF Clone(NM_004991.3) - CDCR289370 from Creative Biomart
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Human MECOM ORF Clone(NM_001105077.3) - CDCR347568 from Creative Biomart
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Human MECOM ORF Clone(NM_001105077.3) - CDCR347569 from Creative Biomart
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Human MECOM ORF Clone(NM_001105077.3) - CDCR347570 from Creative Biomart
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Human MECOM ORF Clone(NM_001105077.3) - CDCR347571 from Creative Biomart
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Human MECOM ORF Clone(NM_001163999.1) - CDCR354470 from Creative Biomart
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Human MECOM ORF Clone(NM_001164000.1) - CDCR354474 from Creative Biomart
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Human MECOM ORF Clone(NM_001163999.1) - CDCR354475 from Creative Biomart
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Human MECOM ORF Clone(NM_001164000.1) - CDCR354476 from Creative Biomart
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Human MECOM ORF clone (NM_001163999.1) - CDCR061684 from Creative biogene
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Human MECOM ORF clone (NM_001105078.3) - CDCR061686 from Creative biogene
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Human MECOM ORF clone (NM_001105077.3) - CDCR061688 from Creative biogene
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Human MECOM ORF clone (NM_004991.3) - CDCR061690 from Creative biogene
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Human MECOM ORF clone (NM_001164000.1) - CDCR061692 from Creative biogene
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Human MECOM ORF Clone (BC069498) - CDCS418994 from Creative biogene
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Human MECOM cDNA Clone(NM_001105077.3) - CDFH011263 from Creative biogene
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Human MECOM cDNA Clone(NM_001163999.1) - CDFH011264 from Creative biogene
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Human MECOM cDNA Clone(NM_001164000.1) - CDFH011265 from Creative biogene
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