MECOM

Gene Symbol MECOM
Entrez Gene 2122
Alt Symbol AML1-EVI-1, EVI1, MDS1, MDS1-EVI1, PRDM3
Species Human
Gene Type protein-coding
Description MDS1 and EVI1 complex locus
Other Description AML1-EVI-1 fusion protein|MDS1 and EVI1 complex locus protein EVI1|MDS1 and EVI1 complex locus protein MDS1|ecotropic virus integration site 1 protein homolog|myelodysplasia syndrome-associated protein 1|oncogene EVI1|zinc finger protein Evi1
Swissprots B7Z8W7 Q13466 Q03112 D3DNP7 A8KA00 Q5HYI1 Q6MZS6 Q13465 Q99917 A1L4F3 Q6FH90 B7ZLQ4 Q16122 B7ZLQ3 Q8NEI5 C9JAK0
Accessions EAW78549 EAW78550 EAW78552 EAW78553 EAW78554 EAW78555 EAW78556 EAW78557 EAW78558 EAW78559 Q03112 Q13465 AA043944 AF164154 AAF04008 AF164155 AAF04009 AF164156 AAF04010 AF164157 AAF04011 AF487422 AAN39687 AF487423 AAN39688 AF487424 AAN39689 AK025934 AK292865 BAF85554 AK304098 BAH14103 AK308404 AK310509 AL700380 BC012450 BC031019 AAH31019 BC069498 AAH69498 BC130520 AAI30521 BC143951 AAI43952 BC143952 AAI43953 BX484790 BX640908 CAE45952 BX647613 CAI46086 CR541866 CAG46664 CR541886 CAG46684 DC347146 DC348381 EU832138 ACE87488 EU832231 ACE86801 GQ352634 ACU31119 S82592 AAB37456 U43292 AAB05839 U43293 AAB05840 X54989 CAA38735 XM_005247213 XP_005247270 XM_005247214 XP_005247271 XM_005247215 XP_005247272 XM_005247219 XP_005247276 XM_005247220 XP_005247277 XM_005247221 XP_005247278 XM_005247223 XP_005247280 XM_005247224 XP_005247281 XM_005247225 XP_005247282 XM_005247226 XP_005247283 XM_011512546 XP_011510848 XM_011512547 XP_011510849 XM_011512548 XP_011510850 NM_001105077 NP_001098547 NM_001105078 NP_001098548 NM_001163999 NP_001157471 NM_001164000 NP_001157472 NM_001205194 NP_001192123 NM_004991 NP_004982 NM_005241 NP_005232
Function Functions as a transcriptional regulator binding to DNA sequences in the promoter region of target genes and regulating positively or negatively their expression. Oncogene which plays a role in development, cell proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved in hematopoiesis. {ECO:0000269|PubMed:10856240, ECO:0000269|PubMed:11568182, ECO:0000269|PubMed:15897867, ECO:0000269|PubMed:16462766, ECO:0000269|PubMed:19767769, ECO:0000269|PubMed:9665135}.
Subcellular Location Nucleus. Nucleus speckle.
Top Pathways Chronic myeloid leukemia, MAPK signaling pathway

Evi-1 Antibody - 2265 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of total cell extracts from MDA-MB231 and SK-OV-3 cells, using Evi-1 antibody. MDS/Evi-1 denotes the fusion between MDS1 and Evi-1 (see reference #6) and Evi-1 delta denotes the truncated form of Evi-1 (see reference #5).

Evi-1 (C50E12) Rabbit mAb - 2593 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone C50E12
Western blot analysis of extracts from various cell lines using Evi-1 (C50E12) Rabbit mAb. MDS/Evi-1 denotes the fusion between MDS1 and Evi-1 (see reference #6) and Evi-1 Δ denotes the truncated form of Evi-1 (see reference #5).

Mds1 (H-45) - sc-99130 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Mds1 (H-45): sc-99130. Western blot analysis of Mds1-Evi-1 expression in CCRF-CEM whole cell lysate.

Mds1 (K-14) - sc-48272 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Mds1 (K-14): sc-48272. Western blot analysis of Mds1-Evi1 fusion protein expression in CCRF-CEM whole cell lysate.

Mds1 (N-12) - sc-48273 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Mds1 (N-12): sc-48273. Immunofluorescence staining of formalin-fixed HepG2 cells showing nuclear localization.

Mds1 (N-20) - sc-48274 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Evi-1 (G-20) - sc-54196 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Evi-1 (G-20): sc-54196. Western blot analysis of Evi-1 expression in Hep G2 (A), SK-OV-3 (B) and CCRF-CEM (C) whole cell lysates.

Evi-1 (P-17) - sc-54198 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Evi-1 (N-20) - sc-8706 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Evi-1 (N-20): sc-8706. Western blot analysis of Evi-1 expression in Hep G2 whole cell lysate.

Evi-1 (2331C1a1) - sc-130025 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
Evi-1 (2331C1a1): sc-130025. Western blot analysis of human recombinant Evi-1 fusion protein.

Anti-EVI1 antibody - ab28457 from Abcam

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-EVI1 antibody (ab28457) at 0.5 µg/ml + fetal lung lysate at 10 µgSecondary HRP conjugated anti rabbit IgG at 1/50000 dilution

Anti-EVI1 antibody - ab196565 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-EVI1 antibody (ab196565) at 1/500 dilutionLane 1 : Mouse kidney cell extractsLane 2 : Mouse heart cell extracts

Anti-EVI1 antibody - ab86306 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-EVI1 antibody (ab86306) at 1 µg/ml (in 5% skim milk / PBS buffer) + Human fetal brain lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-EVI1 antibody - ab123857 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-EVI1 antibody (ab123857) at 1/100 dilution + CEM cell line lysate at 35 µg

Anti-EVI1 antibody - ab129613 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-EVI1 antibody (ab129613) at 1/100 dilution + NIH 3T3 cell lysate at 35 µgdeveloped using the ECL technique

Anti-EVI1 antibody - ab99497 from Abcam

Prices $376.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Anti-EVI1 antibody (ab99497) at 2 µg/ml (for 1 hour) + A549 lysate (in RIPA buffer) at 35 µgdeveloped using the ECL technique

Anti-EVI1 antibody - ab172062 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-EVI1 antibody (ab172062) at 1 µg/mlLane 1 : EVI1 transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 15 µl per lane.

Anti-EVI1 antibody - ab54706 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab54706 EVI1 antibody at 1ug/ml.

Anti-EVI1 antibody [EPR5996] - ab124934 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5996
All lanes : Anti-EVI1 antibody [EPR5996] (ab124934) at 1/1000 dilutionLane 1 : HeLa cell lysateLane 2 : SKOV 3 cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled Goat anti Rabbit at 1/2000 dilution

Anti-EVI1 antibody [MM0729-7U51] - ab201559 from Abcam

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone MM0729-7U51

Anti-PRDM3 antibody - ab65216 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-PRDM3 antibody (ab65216) at 1/500 dilutionLane 1 : Extracts from A549 cellsLane 2 : Extracts from A549 cells, plus immunising peptide

Anti-PRDM3 antibody [47AT612.84.88] - ab3792 from Abcam

Prices $370.00
Sizes 400 µl
Host Mouse
Clonality Monoclonal
Clone 47AT612.84.88

Anti-MECOM / EVI1 Antibody - LS-C65155 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal

Anti-MECOM / EVI1 Antibody (N-Terminus) - LS-C30580 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
A: Marker, B: Rap Cell Lysate

Anti-MECOM / EVI1 Antibody (clone 1E7) - LS-C197667 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1E7
Detection limit for recombinant GST tagged MDS1 is approximately 3 ng/ml as a capture antibody.
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