CSNK1D

Gene Symbol	CSNK1D
Entrez Gene	1453
Alt Symbol	ASPS, CKIdelta, FASPS2, HCKID
Species	Human
Gene Type	protein-coding
Description	casein kinase 1, delta
Other Description	CKI-delta|CKId|casein kinase I isoform delta|tau-protein kinase CSNK1D
Swissprots	Q9BTN5 Q96KZ6 A2I2P2 P48730
Accessions	AAC50808 ABM64211 EAW89758 EAW89759 EAW89760 EAW89761 EAW89762 P48730 AA825280 AB091044 BAC10903 AB209463 BAD92700 AK096950 AK128863 AK291758 BAF84447 AK295638 BAG58511 AK296969 BAG59513 AK303365 BAG64423 AK308852 AK311248 BC003558 AAH03558 BC015775 AAH15775 BC047000 DC334821 EU832350 ACE87607 EU832435 ACE86920 HY000691 U29171 AAC50807 XM_005256336 XP_005256393 XM_005256337 XP_005256394 XR_243518 XR_430028 XR_933922 XR_933923 NM_001893 NP_001884 NM_139062 NP_620693 NR_110578
Function	Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. In balance with PP1, determines the circadian period length through the regulation of the speed and rhythmicity of PER1 and PER2 phospohorylation. Controls PER1 and PER2 nuclear transport and degradation. YAP1 phosphorylation promotes its SCF(beta-TRCP) E3 ubiquitin ligase-mediated ubiquitination and subsequent degradation. DNMT1 phosphorylation reduces its DNA-binding activity. Phosphorylation of ESR1 and AIB1/NCOA3 stimulates their activity and coactivation.
Subcellular Location	Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, perinuclear region. Cell membrane. Cytoplasm, cytoskeleton, spindle. Golgi apparatus. Note=Localized at mitotic spindle microtubules, and at the centrosomes and interphase in interphase cells. Recruited to the spindle apparatus and the centrosomes in response to DNA- damage. Correct subcellular localization requires kinase activity.
Tissue Specificity	Expressed in all tissues examined, including brain, heart, lung, liver, pancreas, kidney, placenta and skeletal muscle. However, kinase activity is not uniform, with highest kinase activity in splenocytes. In blood, highly expressed in hemopoietic cells and mature granulocytes. Also found in monocytes and lymphocytes. {ECO:0000269|PubMed:15070676, ECO:0000269|PubMed:16027726}.
Top Pathways	Hedgehog signaling pathway, Gap junction, Circadian rhythm, Hippo signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human CSNK1D ELISA Kit (Sandwich ELISA) - LS-F8910 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.052 ng/ml Range 0.156-10 ng/ml

Casein kinase I isoform delta (CSNK1D), Human, ELISA Kit - E01C2103 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

Casein Kinase 1 Delta (CSNK1d), ELISA Kit - MBS2024500 from MyBioSource Category ELISA Kit Prices $380.00, $565.00, $765.00, $3,130.00, $5,670.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of human CSNK1d is typically less than 0.052ng/mL. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined by adding two standard deviations to the mean optical density value of twenty zero standard replicates and calculating the corresponding concentration. Range 0.156-10ng/mL

Casein kinase I isoform delta (CSNK1D), ELISA Kit - MBS7207135 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

ELISA Kit for Casein Kinase 1 Delta (CSNK1d) - SED345Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.052ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

ELISA Kit for Casein Kinase 1 Delta (CSNK1d) - SED345Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.052ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA's were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Casein Kinase 1 Delta (CSNK1d), Human, ELISA Kit - DL-CSNK1d-Hu from ARP American Research Products Category ELISA Kit Prices $655.00 Sizes 96 t Range 0.156-10 ng/mL

Human CSNK1d ELISA Kit - abx571582 from Abbexa Category ELISA Kit Sensitivity 0.052 ng/ml Range 0.156 ng/ml - 10 ng/ml

Human CSNK1D ELISA Kit - E006805 from Biobool Category ELISA Kit Sensitivity The minimum detectable dose of human CSNK1d is typically less than 0.052ng/mL. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined by ad

CSNK1D ELISA Kit (Human) (OKCD00381) - OKCD00381 from Aviva Systems Biology Category ELISA Kit Prices $545.00 Sizes 96 wells Sensitivity < 0.052 ng/mL Range 0.156-10 ng/mL

CSNK1d ELISA Kit (Human) (OKDD00210) - OKDD00210 from Aviva Systems Biology Category ELISA Kit Prices $580.00 Sizes 96 wells Sensitivity < 0.052 ng/mL Range 0.156-10 ng/mL

anti-Casein Kinase 1, delta antibody - ARG63958 from Arigo Biolaboratories Category ELISA Kit

Casein Kinase 1 Delta (CSNK1d), ELISA Kit - MBS453096 from MyBioSource Category ELISA Kit Prices $415.00, $550.00, $2,425.00, $4,710.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity <0.052ng/mL Range 0.156-10ng/mL

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