CSNK1D

Gene Symbol	CSNK1D
Entrez Gene	1453
Alt Symbol	ASPS, CKIdelta, FASPS2, HCKID
Species	Human
Gene Type	protein-coding
Description	casein kinase 1, delta
Other Description	CKI-delta|CKId|casein kinase I isoform delta|tau-protein kinase CSNK1D
Swissprots	Q9BTN5 Q96KZ6 A2I2P2 P48730
Accessions	AAC50808 ABM64211 EAW89758 EAW89759 EAW89760 EAW89761 EAW89762 P48730 AA825280 AB091044 BAC10903 AB209463 BAD92700 AK096950 AK128863 AK291758 BAF84447 AK295638 BAG58511 AK296969 BAG59513 AK303365 BAG64423 AK308852 AK311248 BC003558 AAH03558 BC015775 AAH15775 BC047000 DC334821 EU832350 ACE87607 EU832435 ACE86920 HY000691 U29171 AAC50807 XM_005256336 XP_005256393 XM_005256337 XP_005256394 XR_243518 XR_430028 XR_933922 XR_933923 NM_001893 NP_001884 NM_139062 NP_620693 NR_110578
Function	Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. In balance with PP1, determines the circadian period length through the regulation of the speed and rhythmicity of PER1 and PER2 phospohorylation. Controls PER1 and PER2 nuclear transport and degradation. YAP1 phosphorylation promotes its SCF(beta-TRCP) E3 ubiquitin ligase-mediated ubiquitination and subsequent degradation. DNMT1 phosphorylation reduces its DNA-binding activity. Phosphorylation of ESR1 and AIB1/NCOA3 stimulates their activity and coactivation.
Subcellular Location	Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, perinuclear region. Cell membrane. Cytoplasm, cytoskeleton, spindle. Golgi apparatus. Note=Localized at mitotic spindle microtubules, and at the centrosomes and interphase in interphase cells. Recruited to the spindle apparatus and the centrosomes in response to DNA- damage. Correct subcellular localization requires kinase activity.
Tissue Specificity	Expressed in all tissues examined, including brain, heart, lung, liver, pancreas, kidney, placenta and skeletal muscle. However, kinase activity is not uniform, with highest kinase activity in splenocytes. In blood, highly expressed in hemopoietic cells and mature granulocytes. Also found in monocytes and lymphocytes. {ECO:0000269|PubMed:15070676, ECO:0000269|PubMed:16027726}.
Top Pathways	Hedgehog signaling pathway, Gap junction, Circadian rhythm, Hippo signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human Casein Kinase 1 delta full length protein - ab103955 from Abcam Category Protein Prices $239.00, $352.00 Sizes 5 µg, 10 µg Source Baculovirus infected sf9 cells Species Human

Casein Kinase 1 delta peptide - ab48070 from Abcam Category Peptide Prices $290.00 Sizes 100 µg

Human Casein Kinase 1 delta full length protein - ab40527 from Abcam Category Protein Prices $235.00 Sizes 50 µg Source E. coli Species Human

Human Casein Kinase 1 delta full length protein - ab180293 from Abcam Category Protein Prices $357.00 Sizes 100 µg Source E. coli Species Human

CSNK1D Antibody Blocking Peptide - LS-E3513 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CSNK1D Antibody Blocking Peptide - LS-E8926 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CSNK1D Antibody Blocking Peptide - LS-E26089 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CSNK1D Antibody Blocking Peptide - LS-E18658 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Casein Kinase 1 delta Recombinant Protein - H00001453-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Species Human

Casein Kinase 1 delta Partial Recombinant Protein - H00001453-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Casein Kinase 1 delta Peptide - P2489 from Novus Biologicals Category Peptide Species Human

CSNK1D-Antibody-C-term-Blocking-peptide - BP7402a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Casein Kinase 1 delta blocking peptide - GTX89349-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat

CSNK1D protein (His tag) - 80R-3823 from Fitzgerald Category Protein Prices $275.00 Sizes 100 µg Source E.coli

Casein Kinase 1 delta Peptide - AC21-0917-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

Casein kinase I delta (1-409, His-tag) - AR51510PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

Casein kinase I delta (1-409, His-tag) - AR51510PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

Casein kinase I delta - H00001453-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

Casein kinase I delta - H00001453-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Casein kinase I delta - H00001453-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Casein kinase I delta - P5524 from Acris Antibodies Category Protein Prices $790.00 Sizes 5 µg Species Human

CSNK1D, 1-409aa, Human, His tag, E.coli - 01-P2690 from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Species Human

Casein Kinase 1 Peptide - 45-362P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human

CSNK1D fusion protein - ag5856 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

CSNK1D fusion protein - Ag6318 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

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