| Gene Symbol | CSNK1D |
|---|---|
| Entrez Gene | 1453 |
| Alt Symbol | ASPS, CKIdelta, FASPS2, HCKID |
| Species | Human |
| Gene Type | protein-coding |
| Description | casein kinase 1, delta |
| Other Description | CKI-delta|CKId|casein kinase I isoform delta|tau-protein kinase CSNK1D |
| Swissprots | Q9BTN5 Q96KZ6 A2I2P2 P48730 |
| Accessions | AAC50808 ABM64211 EAW89758 EAW89759 EAW89760 EAW89761 EAW89762 P48730 AA825280 AB091044 BAC10903 AB209463 BAD92700 AK096950 AK128863 AK291758 BAF84447 AK295638 BAG58511 AK296969 BAG59513 AK303365 BAG64423 AK308852 AK311248 BC003558 AAH03558 BC015775 AAH15775 BC047000 DC334821 EU832350 ACE87607 EU832435 ACE86920 HY000691 U29171 AAC50807 XM_005256336 XP_005256393 XM_005256337 XP_005256394 XR_243518 XR_430028 XR_933922 XR_933923 NM_001893 NP_001884 NM_139062 NP_620693 NR_110578 |
| Function | Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. In balance with PP1, determines the circadian period length through the regulation of the speed and rhythmicity of PER1 and PER2 phospohorylation. Controls PER1 and PER2 nuclear transport and degradation. YAP1 phosphorylation promotes its SCF(beta-TRCP) E3 ubiquitin ligase-mediated ubiquitination and subsequent degradation. DNMT1 phosphorylation reduces its DNA-binding activity. Phosphorylation of ESR1 and AIB1/NCOA3 stimulates their activity and coactivation. |
| Subcellular Location | Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, perinuclear region. Cell membrane. Cytoplasm, cytoskeleton, spindle. Golgi apparatus. Note=Localized at mitotic spindle microtubules, and at the centrosomes and interphase in interphase cells. Recruited to the spindle apparatus and the centrosomes in response to DNA- damage. Correct subcellular localization requires kinase activity. |
| Tissue Specificity | Expressed in all tissues examined, including brain, heart, lung, liver, pancreas, kidney, placenta and skeletal muscle. However, kinase activity is not uniform, with highest kinase activity in splenocytes. In blood, highly expressed in hemopoietic cells and mature granulocytes. Also found in monocytes and lymphocytes. {ECO:0000269|PubMed:15070676, ECO:0000269|PubMed:16027726}. |
| Top Pathways | Hedgehog signaling pathway, Gap junction, Circadian rhythm, Hippo signaling pathway |