Gene Symbol | HHEX |
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Entrez Gene | 3087 |
Alt Symbol | HEX, HMPH, HOX11L-PEN, PRH, PRHX |
Species | Human |
Gene Type | protein-coding |
Description | hematopoietically expressed homeobox |
Other Description | hematopoietically-expressed homeobox protein HHEX|homeobox protein HEX|homeobox protein PRH|homeobox, hematopoietically expressed|proline-rich homeodomain-containing transcription factor |
Swissprots | B1AQ17 Q03014 Q96CE9 |
Accessions | AAK12833 EAW50087 EAW50088 Q03014 AA810064 AK309463 AK314891 BAG37405 BC014336 AAH14336 BC015110 AAH15110 BC050638 AAH50638 BI823658 BM543214 DB504532 EU446478 ABZ92007 L16499 AAA02988 X67235 CAA47661 Z21533 CAA79730 NM_002729 NP_002720 |
Function | Recognizes the DNA sequence 5'-ATTAA-3'. Transcriptional repressor. May play a role in hematopoietic differentiation. Establishes anterior identity at two levels; acts early to enhance canonical WNT-signaling by repressing expression of TLE4, and acts later to inhibit NODAL-signaling by directly targeting NODAL (By similarity). {ECO:0000250}. |
Subcellular Location | Nucleus {ECO:0000305}. |
Tissue Specificity | Liver and promyelocytic leukemia cell line HL- 60. {ECO:0000269|PubMed:1360645, ECO:0000269|PubMed:8096636, ECO:0000269|PubMed:8103988}. |
Top Pathways | Maturity onset diabetes of the young, Transcriptional misregulation in cancer |
Hex CRISPR/Cas9 KO Plasmid (h) - sc-403827 from Santa Cruz Biotechnology
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Hex HDR Plasmid (h) - sc-403827-HDR from Santa Cruz Biotechnology
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Hex Double Nickase Plasmid (h) - sc-403827-NIC from Santa Cruz Biotechnology
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Hex Double Nickase Plasmid (h2) - sc-403827-NIC-2 from Santa Cruz Biotechnology
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Hex CRISPR Activation Plasmid (h) - sc-403827-ACT from Santa Cruz Biotechnology
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Hex CRISPR Activation Plasmid (h2) - sc-403827-ACT-2 from Santa Cruz Biotechnology
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Hex Lentiviral Activation Particles (h) - sc-403827-LAC from Santa Cruz Biotechnology
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Hex Lentiviral Activation Particles (h2) - sc-403827-LAC-2 from Santa Cruz Biotechnology
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Hex siRNA (h) - sc-43831 from Santa Cruz Biotechnology
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Hex shRNA Plasmid (h) - sc-43831-SH from Santa Cruz Biotechnology
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Hex shRNA (h) Lentiviral Particles - sc-43831-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU052411 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1485 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1485 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR07027 from Sigma-Aldrich
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HHEX siRNA (Human) - CRH2103 from Cohesion Biosciences
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HHEX RNAi - H00003087-R01 from Novus Biologicals
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HHEX - MBS829106 from MyBioSource
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shRNA set against Human HHEX (NM_002729.4) - SHH311977 from Creative biogene
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shRNA set against Human HHEX(NM_002729.4) - SHH120071 from Creative biogene
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Human HHEX siRNA - orb262605 from Biorbyt
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HHEX shRNA Plasmid (Human) - CHH2103 from Cohesion Biosciences
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HHEX miRNA 3'UTR clone - MiUTR1H-04490 from Creative biogene
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