Gene Symbol | ASUN |
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Entrez Gene | 55726 |
Alt Symbol | C12orf11, GCT1, Mat89Bb, NET48, SPATA30 |
Species | Human |
Gene Type | protein-coding |
Description | asunder spermatogenesis regulator |
Other Description | asunder, spermatogenesis regulator homolog (Drosphila)|cell cycle regulator Mat89Bb homolog|germ cell tumor 1|protein asunder homolog|sarcoma antigen NY-SAR-95|spermatogenesis associated 30 |
Swissprots | B4DNK1 Q9NVM9 Q9BTX2 Q86WE2 Q9NVM5 Q9NTB6 Q96HM2 |
Accessions | EAW96538 EAW96539 Q9NVM9 AF274950 AAK07527 AK001222 BAA91565 AK001492 BAA91721 AK001499 BAA91725 AK225336 AK297948 BAG60263 AL137401 CAB70726 AY211927 AAO65180 BC003081 AAH03081 BC008368 AAH08368 BM684866 DB239903 XM_005253422 XP_005253479 XM_011520749 XP_011519051 XM_011520750 XP_011519052 XM_011520751 XP_011519053 XM_011520752 XP_011519054 XM_011520753 XP_011519055 XR_931311 NM_018164 NP_060634 |
Function | Crucial regulator of the mitotic cell cycle and development. At prophase, required for dynein anchoring to the nuclear envelope important for proper centrosome-nucleus coupling. At G2/M phase, may be required for proper spindle formation and execution of cytokinesis. {ECO:0000269|PubMed:15737938, ECO:0000269|PubMed:23097494}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:23097494}. |
Tissue Specificity | Widely expressed. Tends to be up-regulated in seminomas compared to normal testis. {ECO:0000269|PubMed:12414650}. |
C12orf11 CRISPR/Cas9 KO Plasmid (h) - sc-412584 from Santa Cruz Biotechnology
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C12orf11 HDR Plasmid (h) - sc-412584-HDR from Santa Cruz Biotechnology
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C12orf11 Double Nickase Plasmid (h) - sc-412584-NIC from Santa Cruz Biotechnology
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C12orf11 Double Nickase Plasmid (h2) - sc-412584-NIC-2 from Santa Cruz Biotechnology
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C12orf11 CRISPR Activation Plasmid (h) - sc-412584-ACT from Santa Cruz Biotechnology
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C12orf11 CRISPR Activation Plasmid (h2) - sc-412584-ACT-2 from Santa Cruz Biotechnology
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C12orf11 Lentiviral Activation Particles (h) - sc-412584-LAC from Santa Cruz Biotechnology
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C12orf11 Lentiviral Activation Particles (h2) - sc-412584-LAC-2 from Santa Cruz Biotechnology
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C12orf11 siRNA (h) - sc-95921 from Santa Cruz Biotechnology
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C12orf11 shRNA Plasmid (h) - sc-95921-SH from Santa Cruz Biotechnology
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C12orf11 shRNA (h) Lentiviral Particles - sc-95921-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU065381 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN4239 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND4239 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR03256 from Sigma-Aldrich
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ASUN siRNA (Human) - CRJ0865 from Cohesion Biosciences
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ASUN - MBS8232803 from MyBioSource
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shRNA set against Human C12orf11 (NM_018164.2) - SHH249030 from Creative biogene
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Human ASUN siRNA - orb271366 from Biorbyt
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ASUN shRNA Plasmid (Human) - CHJ0865 from Cohesion Biosciences
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ASUN miRNA 3'UTR clone - MiUTR1H-01055 from Creative biogene
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