| Gene Symbol |
CCNB1IP1
|
| Entrez Gene |
57820
|
| Alt Symbol |
C14orf18, HEI10
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
|
| Other Description |
E3 ubiquitin-protein ligase CCNB1IP1|human enhancer of invasion 10
|
| Swissprots |
Q9NPC3
|
| Accessions |
CAI93603 EAW66479 Q9NPC3 AA101731 AF216381 AAF36386 AI301662 AK026233 BAB15403 AK225253 AK225451 AK226037 AK309183 AL161994 CAB82326 AM393093 CAL37971 AM393651 CAL38527 BC000369 AAH00369 BC001218 AAH01218 BC004435 AAH04435 BI763317 BI771433 BI917081 BM741413 BX161423 CAD61896 BX161424 CAD61897 BX247978 CAD62312 BX334446 CB113193 DB029392 NM_182851 NM_021178 NP_067001 NM_182849 NP_878269 NM_182852 NP_878272
|
| Function |
Ubiquitin E3 ligase that acts as a limiting factor for crossing-over during meiosis: required during zygonema to limit the colocalization of RNF212 with MutS-gamma-associated recombination sites and thereby establish early differentiation of crossover and non-crossover sites. Later, it is directed by MutL- gamma to stably accumulate at designated crossover sites. Probably promotes the dissociation of RNF212 and MutS-gamma to allow the progression of recombination and the implementation of the final steps of crossing over (By similarity). Modulates cyclin-B levels and participates in the regulation of cell cycle progression through the G2 phase. Overexpression causes delayed entry into mitosis. {ECO:0000250}.
|
| Subcellular Location |
Nucleus. Chromosome. Note=Associates to the synaptonemal complex.
|
| Tissue Specificity |
Highly expressed in heart. Detected at intermediate levels in liver and kidney, and at low levels in placenta, brain and lung. {ECO:0000269|PubMed:12612082}.
|