| Gene Symbol |
FAM120A
|
| Entrez Gene |
23196
|
| Alt Symbol |
C9orf10, DNAPTP1, DNAPTP5, OSSA
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
family with sequence similarity 120A
|
| Other Description |
DNA polymerase-transactivated protein 1|DNA polymerase-transactivated protein 5|constitutive coactivator of PPAR-gamma-like protein 1|oxidative stess-associated Src activator|oxidative stress-associated Src activator
|
| Swissprots |
Q4VXF4 A6NGU0 O60649 Q14688 Q86V69 Q9NZB2 Q9NZB1 Q4VXF5 Q4VXG2 Q96I21 C4AMC6
|
| Accessions |
EAW62863 EAW62864 EAW62865 EAW62866 Q9NZB2 AF055017 AAC09364 AF214737 AAF72866 AF214738 AAF72867 AK091785 AK096349 AW949787 AY266457 AAP31031 AY450389 AAR21082 AY450393 AAR21086 BC007879 AAH07879 BC034935 BC075701 BC098584 AAH98584 BC111736 AAI11737 BQ020345 BQ421167 BX326996 CA310462 CA419293 CB989774 CD110412 CF135376 D80005 BAA11500 R40697 XM_005251842 XP_005251899 XM_011518412 XP_011516714 XM_011518413 XP_011516715 XM_011518414 XP_011516716 XM_011518415 XP_011516717 XM_011518416 XP_011516718 NM_001286722 NP_001273651 NM_001286723 NP_001273652 NM_001286724 NP_001273653 NM_014612 NP_055427
|
| Function |
May participate in mRNA transport in the cytoplasm (By similarity). Critical component of the oxidative stress-induced survival signaling. Activates src family kinases and acts as a scaffolding protein enabling src family kinases to phosphorylate and activate PI3-kinase. Binds RNA and promotes the secretion of IGF-II. May play a pivotal role in the progression of scirrhous- type gastric cancer by supporting cancer cell survival in environments with various oxidative stresses. {ECO:0000250, ECO:0000269|PubMed:19015244}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:19015244}. Cell membrane {ECO:0000269|PubMed:19015244}; Peripheral membrane protein {ECO:0000269|PubMed:19015244}; Cytoplasmic side {ECO:0000269|PubMed:19015244}. Note=Translocates to plasma membrane upon ultraviolet exposure.
|
| Tissue Specificity |
Ubiquitously expressed. Highly expressed in scirrhous-type gastric cancer tissues compared with normal gastric mucosa (at protein level). {ECO:0000269|PubMed:14585507, ECO:0000269|PubMed:19015244}.
|