| Gene Symbol |
ASB10
|
| Entrez Gene |
136371
|
| Alt Symbol |
GLC1F
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ankyrin repeat and SOCS box containing 10
|
| Other Description |
ankyrin repeat and SOCS box protein 10
|
| Swissprots |
Q6ZUL6 A0AVH0 Q8WXI3
|
| Accessions |
EAL24504 EAW54020 EAW54021 EAW54022 Q8WXI3 AF417920 AAL59159 AK055536 AK125565 BAC86204 AK315114 BC126351 AAI26352 DA898875 XM_005249949 XP_005250006 NM_001142459 NP_001135931 NM_001142460 NP_001135932 NM_080871 NP_543147
|
| Function |
May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:22156576}. Nucleus {ECO:0000269|PubMed:22156576}. Note=In the ciliary body, it is detected in the cytoplasm and perinuclear region of the pigmented ciliary epithelial layer. In the retina, it is detected in the nuclei of retinal ganglion cells.
|
| Tissue Specificity |
Expressed in the eye. The highest expression is observed in the iris, with moderate levels in the trabecular meshwork (TM), the lamina, and the optic nerve; slightly lower levels in the ciliary body, retina, and choroid; and very low levels in the lens. {ECO:0000269|PubMed:22156576}.
|