| Gene Symbol |
HOMER3
|
| Entrez Gene |
9454
|
| Alt Symbol |
HOMER-3, VESL3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
homer scaffolding protein 3
|
| Other Description |
Homer, neuronal immediate early gene, 3|homer homolog 3|homer protein homolog 3
|
| Swissprots |
E9PCW9 O95350 Q9NSB9 Q9NSC5 Q9NSC1 Q9NSC0 O14580
|
| Accessions |
AAB81545 EAW84762 EAW84763 EAW84764 EAW84765 Q9NSC5 AF093265 AAC71029 AK124450 BAG54040 AK313995 BAG36707 AL529052 AW606967 BC012113 AAH12113 BM915739 BT019464 AAV38271 CN284196 DQ892557 ABM83483 DQ895771 ABM86697 Y17573 CAB75536 Y18894 CAB75543 Y18895 CAB75544 Y18896 CAB75545 XM_006722943 XP_006723006 XM_006722944 XP_006723007 NM_001145721 NP_001139193 NM_001145722 NP_001139194 NM_001145724 NP_001139196 NM_004838 NP_004829 NR_027297
|
| Function |
Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Note=Postsynaptic density of neuronal cells. {ECO:0000250}.
|
| Top Pathways |
Glutamatergic synapse
|