GALNT11
| Gene Symbol | GALNT11 |
|---|---|
| Entrez Gene | 63917 |
| Alt Symbol | GALNAC-T11, GALNACT11 |
| Species | Human |
| Gene Type | protein-coding |
| Description | polypeptide N-acetylgalactosaminyltransferase 11 |
| Other Description | UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 11|UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11 (GalNAc-T11)|polypeptide GalNAc transferase 11|pp-GaNTase 11|protein-UDP acetylgalactosaminyltransferase 11 |
| Swissprots | Q9H6Z5 Q9UDR8 Q8NCW6 Q9H6C2 B3KWF4 Q6PCD1 |
| Accessions | AAD45821 CAD38481 CCQ43678 EAL24518 EAW53975 EAW53976 Q8NCW6 AK025287 BAB15105 AK026056 BAB15338 AK124934 BAG54116 AK128545 AK296097 BAH12255 AK298911 BAH12901 BC059377 AAH59377 BC167834 AAI67834 BE349504 BM998376 CN309655 DA308896 DA679635 DA748534 Y12434 CAC79625 XM_006716082 XP_006716145 XM_006716083 XP_006716146 XM_006716084 XP_006716147 NM_001304514 NP_001291443 NM_022087 NP_071370 |
| Function | Polypeptide N-acetylgalactosaminyltransferase that catalyzes the initiation of protein O-linked glycosylation and is involved in left/right asymmetry by mediating O-glycosylation of NOTCH1. O-glycosylation of NOTCH1 promotes activation of NOTCH1, modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO). Polypeptide N- acetylgalactosaminyltransferases catalyze the transfer of an N- acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Displays the same enzyme activity toward MUC1, MUC4, and EA2 than GALNT1. Not involved in glycosylation of erythropoietin (EPO). {ECO:0000269|PubMed:11925450, ECO:0000269|PubMed:24226769}. |
| Subcellular Location | Golgi apparatus membrane {ECO:0000269|PubMed:11925450}; Single-pass type II membrane protein {ECO:0000269|PubMed:11925450}. |
| Tissue Specificity | Highly expressed in kidney. Expressed at intermediate level in brain, heart and skeletal muscle. Weakly expressed other tissues. In kidney, it is strongly expressed in tubules but not expressed in glomeruli. {ECO:0000269|PubMed:11925450}. |
| Top Pathways | Mucin type O-Glycan biosynthesis |
GalNAc-T11 CRISPR/Cas9 KO Plasmid (h) - sc-409314 from Santa Cruz Biotechnology
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GalNAc-T11 HDR Plasmid (h) - sc-409314-HDR from Santa Cruz Biotechnology
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GalNAc-T11 Double Nickase Plasmid (h) - sc-409314-NIC from Santa Cruz Biotechnology
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GalNAc-T11 Double Nickase Plasmid (h2) - sc-409314-NIC-2 from Santa Cruz Biotechnology
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GalNAc-T11 CRISPR Activation Plasmid (h) - sc-409314-ACT from Santa Cruz Biotechnology
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GalNAc-T11 CRISPR Activation Plasmid (h2) - sc-409314-ACT-2 from Santa Cruz Biotechnology
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GalNAc-T11 Lentiviral Activation Particles (h) - sc-409314-LAC from Santa Cruz Biotechnology
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GalNAc-T11 Lentiviral Activation Particles (h2) - sc-409314-LAC-2 from Santa Cruz Biotechnology
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GalNAc-T11 siRNA (h) - sc-75086 from Santa Cruz Biotechnology
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GalNAc-T11 shRNA Plasmid (h) - sc-75086-SH from Santa Cruz Biotechnology
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GalNAc-T11 shRNA (h) Lentiviral Particles - sc-75086-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU083811 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN9103 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9103 from Sigma-Aldrich
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GALNT11 siRNA (Human) - CRJ1860 from Cohesion Biosciences
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GALNT11 RNAi - H00063917-R01 from Novus Biologicals
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GALNT11 - MBS8236761 from MyBioSource
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shRNA set against Human Galnt11 (NM_022087.2) - SHH298981 from Creative biogene
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shRNA set against Human GALNT11(NM_022087.2) - SHH075971 from Creative biogene
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Human GALNT11 siRNA - orb272361 from Biorbyt
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GALNT11 shRNA Plasmid (Human) - CHJ1860 from Cohesion Biosciences
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GALNT11 miRNA 3'UTR clone - MiUTR1H-03936 from Creative biogene
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