ABCA4

Gene Symbol	ABCA4
Entrez Gene	24
Alt Symbol	ABC10, ABCR, ARMD2, CORD3, FFM, RMP, RP19, STGD, STGD1
Species	Human
Gene Type	protein-coding
Description	ATP-binding cassette, sub-family A (ABC1), member 4
Other Description	ATP binding cassette transporter|ATP-binding cassette sub-family A member 4|ATP-binding cassette transporter, retinal-specific|ATP-binding transporter, retina-specific|RIM ABC transporter|RIM protein|photoreceptor rim protein|retina-specific ABC transporter|retinal-specific ATP-binding cassette transporter|stargardt disease protein
Swissprots	Q0QD48 O60438 P78363 Q4LE31 O15112 O60915
Accessions	AAP33155 CAA75729 EAW73056 EAW73057 EAW73058 P78363 AB210040 BAE06122 AF000148 AAC23915 AF001945 AAC05632 AK295818 BAG58635 AK296896 BAH12450 AK301733 BAG63198 AK301764 BAG63224 AK310492 AL712362 BC172262 AAI72262 BC172565 AAI72565 BM686882 CR627391 CAH10486 DQ426859 ABD90529 U66691 U88667 AAC51144 NM_000350 NP_000341
Function	In the visual cycle, acts as an inward-directed retinoid flipase, retinoid substrates imported by ABCA4 from the extracellular or intradiscal (rod) membrane surfaces to the cytoplasmic membrane surface are all-trans-retinaldehyde (ATR) and N-retinyl-phosphatidyl-ethanolamine (NR-PE). Once transported to the cytoplasmic surface, ATR is reduced to vitamin A by trans- retinol dehydrogenase (tRDH) and then transferred to the retinal pigment epithelium (RPE) where it is converted to 11-cis-retinal. May play a role in photoresponse, removing ATR/NR-PE from the extracellular photoreceptor surfaces during bleach recovery. {ECO:0000269|PubMed:10075733}.
Subcellular Location	Membrane {ECO:0000269|PubMed:10075733}; Multi-pass membrane protein {ECO:0000269|PubMed:10075733}. Note=Localized to outer segment disk edges of rods and cones, with around one million copies/photoreceptor.
Tissue Specificity	Retinal-specific. Seems to be exclusively found in the rims of rod photoreceptor cells.
Top Pathways	ABC transporters

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• Cell/Tissue/Blood Products

Human ABCA4 peptide - ab87350 from Abcam Category Peptide Prices $176.00 Sizes 100 µg

Human ABCA4 protein fragment - ab114660 from Abcam Category Protein Prices $420.00 Sizes 10 µg Source Wheat germ Species Human

ABCA4 Antibody Blocking Peptide - LS-E26747 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ABCA4 Antibody Blocking Peptide - LS-E27004 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human ABCA4 Protein - H00000024-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

ABCA4 (aa1336-49) blocking peptide - GTX88465-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

ABCA4 Immunizing peptide - orb55116 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

Goat anti ABCA4 antibody Immunizing peptide - orb50479 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

ABCA4 Blocking Peptide - abx161244 from Abbexa Category Peptide Species Human, Mouse, Rat, Dog, Monkey

ABCA4 Peptide - AC21-1583-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

ABCA4 Peptide - AC21-1828-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

ABCA4 - H00000024-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

ABCA4 - H00000024-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

ABCA4 Peptide - 46-923P from ProSci Category Peptide

ABCA4 Peptide - 46-788P from ProSci Category Peptide

Recombinant ATP Binding Cassette Transporter A4 (ABCA4) - RPD620Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

ABCA4 Blocking Peptide - CBP3743 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Dog, Monkey

Recombinant ATP Binding Cassette Transporter A4 (ABCA4) - RPD620Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human IL-24 (Carrier-free) - 21-7153 from Tonbo Biosciences Category Protein Prices $76.00, $175.00, $769.00, $2,295.00 Sizes 5 µg, 20 µg, 100 µg, 500 µg Source CHO cells Species Human

ABCA4, Peptide - MBS425337 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human

ABCA4, Peptide - MBS658639 from MyBioSource Category Peptide Prices $340.00 Sizes 100 µg

ABCA4, Peptide - MBS428537 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Dog

ABCA4 Peptide, Human - M34GP00034H from Creative Peptides Category Peptide Source Synthetic. Species Human

ABCA4 Recombinant Protein (OPCD01006) - OPCD01006 from Aviva Systems Biology Category Protein Source E.coli Species Human

Recombinant Human Retinal-specific ATP-binding cassette transporter(ABCA4) ,partial,Yeast - CSB-YP001040HU from Cusabio Category Protein Source Yeast Species Human

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