ABCA4

Gene Symbol ABCA4
Entrez Gene 24
Alt Symbol ABC10, ABCR, ARMD2, CORD3, FFM, RMP, RP19, STGD, STGD1
Species Human
Gene Type protein-coding
Description ATP-binding cassette, sub-family A (ABC1), member 4
Other Description ATP binding cassette transporter|ATP-binding cassette sub-family A member 4|ATP-binding cassette transporter, retinal-specific|ATP-binding transporter, retina-specific|RIM ABC transporter|RIM protein|photoreceptor rim protein|retina-specific ABC transporter|retinal-specific ATP-binding cassette transporter|stargardt disease protein
Swissprots Q0QD48 O60438 P78363 Q4LE31 O15112 O60915
Accessions AAP33155 CAA75729 EAW73056 EAW73057 EAW73058 P78363 AB210040 BAE06122 AF000148 AAC23915 AF001945 AAC05632 AK295818 BAG58635 AK296896 BAH12450 AK301733 BAG63198 AK301764 BAG63224 AK310492 AL712362 BC172262 AAI72262 BC172565 AAI72565 BM686882 CR627391 CAH10486 DQ426859 ABD90529 U66691 U88667 AAC51144 NM_000350 NP_000341
Function In the visual cycle, acts as an inward-directed retinoid flipase, retinoid substrates imported by ABCA4 from the extracellular or intradiscal (rod) membrane surfaces to the cytoplasmic membrane surface are all-trans-retinaldehyde (ATR) and N-retinyl-phosphatidyl-ethanolamine (NR-PE). Once transported to the cytoplasmic surface, ATR is reduced to vitamin A by trans- retinol dehydrogenase (tRDH) and then transferred to the retinal pigment epithelium (RPE) where it is converted to 11-cis-retinal. May play a role in photoresponse, removing ATR/NR-PE from the extracellular photoreceptor surfaces during bleach recovery. {ECO:0000269|PubMed:10075733}.
Subcellular Location Membrane {ECO:0000269|PubMed:10075733}; Multi-pass membrane protein {ECO:0000269|PubMed:10075733}. Note=Localized to outer segment disk edges of rods and cones, with around one million copies/photoreceptor.
Tissue Specificity Retinal-specific. Seems to be exclusively found in the rims of rod photoreceptor cells.
Top Pathways ABC transporters

ABCA4 CRISPR/Cas9 KO Plasmid (h) - sc-401830 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ABCA4 HDR Plasmid (h) - sc-401830-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ABCA4 Double Nickase Plasmid (h) - sc-401830-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ABCA4 Double Nickase Plasmid (h2) - sc-401830-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ABCA4 CRISPR Activation Plasmid (h) - sc-401830-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ABCA4 CRISPR Activation Plasmid (h2) - sc-401830-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ABCA4 Lentiviral Activation Particles (h) - sc-401830-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ABCA4 Lentiviral Activation Particles (h2) - sc-401830-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ABCA4 siRNA (h) - sc-41140 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ABCA4 shRNA Plasmid (h) - sc-41140-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ABCA4 shRNA (h) Lentiviral Particles - sc-41140-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU101241 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN1687 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1687 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR03214 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr03214

ABCA4 siRNA (Human) - CRH0016 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ABCA4 RNAi - H00000024-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

ABCA4 - MBS8201637 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human ABCA4 (NM_000350.2) - SHH228862 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human ABCA4(NM_000350.2) - SHG022785 from Creative biogene

Category siRNA
Species Reactivities Human

Human ABCA4 siRNA - orb260518 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ABCA4 shRNA Plasmid (Human) - CHH0016 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

ABCA4 miRNA 3'UTR clone - MiUTR1H-00021 from Creative biogene

Species Reactivities Human
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