| Gene Symbol |
SPPL2B
|
| Entrez Gene |
56928
|
| Alt Symbol |
IMP-4, IMP4, PSH4, PSL1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
signal peptide peptidase like 2B
|
| Other Description |
SPP-like 2B|intramembrane protease 4|presenilin homologous protein 4|presenilin-like protein 1|signal peptide peptidase-like 2B
|
| Swissprots |
O60365 Q9BUY6 Q567S3 D6W609 Q9P1Z6 Q9NPN2 Q8IUH9 Q8TCT7 Q9H3M4
|
| Accessions |
AAC05601 AAG45441 EAW69383 EAW69384 EAW69385 EAW69386 EAW69387 EAW69388 Q8TCT7 AB040965 BAA96056 AJ345027 CAC87788 AJ420897 CAD13134 AK226130 AK308973 AK309122 AL365405 CAB96951 AY169315 AAO12540 BC001788 AAH01788 BC028391 AAH28391 BC093046 AAH93046 BU733058 XM_011528138 XP_011526440 XM_011528139 XP_011526441 XM_011528140 XP_011526442 NM_001077238 NP_001070706 NM_152988 NP_694533
|
| Function |
Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in ITM2B and TNF processing. Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF- alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus. May play a role in the regulation of innate and adaptive immunity. {ECO:0000269|PubMed:16829951, ECO:0000269|PubMed:16829952, ECO:0000269|PubMed:17965014, ECO:0000269|PubMed:19114711, ECO:0000269|PubMed:22194595}.
|
| Subcellular Location |
Golgi apparatus membrane {ECO:0000269|PubMed:15998642, ECO:0000269|PubMed:17965014}; Multi- pass membrane protein {ECO:0000269|PubMed:15998642, ECO:0000269|PubMed:17965014}. Note=targeted through the entire secretory pathway to endosomes/lysosomes.
|
| Tissue Specificity |
Expressed predominantly in adrenal cortex and mammary gland. {ECO:0000269|PubMed:15385547}.
|