SPPL2B

Gene Symbol SPPL2B
Entrez Gene 56928
Alt Symbol IMP-4, IMP4, PSH4, PSL1
Species Human
Gene Type protein-coding
Description signal peptide peptidase like 2B
Other Description SPP-like 2B|intramembrane protease 4|presenilin homologous protein 4|presenilin-like protein 1|signal peptide peptidase-like 2B
Swissprots O60365 Q9BUY6 Q567S3 D6W609 Q9P1Z6 Q9NPN2 Q8IUH9 Q8TCT7 Q9H3M4
Accessions AAC05601 AAG45441 EAW69383 EAW69384 EAW69385 EAW69386 EAW69387 EAW69388 Q8TCT7 AB040965 BAA96056 AJ345027 CAC87788 AJ420897 CAD13134 AK226130 AK308973 AK309122 AL365405 CAB96951 AY169315 AAO12540 BC001788 AAH01788 BC028391 AAH28391 BC093046 AAH93046 BU733058 XM_011528138 XP_011526440 XM_011528139 XP_011526441 XM_011528140 XP_011526442 NM_001077238 NP_001070706 NM_152988 NP_694533
Function Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in ITM2B and TNF processing. Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF- alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus. May play a role in the regulation of innate and adaptive immunity. {ECO:0000269|PubMed:16829951, ECO:0000269|PubMed:16829952, ECO:0000269|PubMed:17965014, ECO:0000269|PubMed:19114711, ECO:0000269|PubMed:22194595}.
Subcellular Location Golgi apparatus membrane {ECO:0000269|PubMed:15998642, ECO:0000269|PubMed:17965014}; Multi- pass membrane protein {ECO:0000269|PubMed:15998642, ECO:0000269|PubMed:17965014}. Note=targeted through the entire secretory pathway to endosomes/lysosomes.
Tissue Specificity Expressed predominantly in adrenal cortex and mammary gland. {ECO:0000269|PubMed:15385547}.

SPPL2b (E-12) - sc-132846 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

SPPL2b (K-12) - sc-132847 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

SPPL2b (N-13) - sc-132848 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

SPPL2b (F-19) - sc-102122 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Rabbit
Clonality Polyclonal
SPPL2b (F-19): sc-102122. Immunoperoxidase staining of formalin fixed, paraffin-embedded human kidney tissue showing cytoplasmic staining.

Anti-Signal peptide peptidase-like 2B antibody - ab43856 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Signal peptide peptidase-like 2B antibody (ab43856) at 1 µg/mlLane 1 : WI38 (Human lung fibroblast cell line) Whole Cell Lysate (ab3960)Lane 2 : Thymus (Human) Tissue Lysate - adult normal tissue (ab30146)Lysates/proteins at 10 µg per lane.SecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutionPerformed under reducing conditions.

Anti-Signal peptide peptidase-like 2B antibody - N-terminal - ab179691 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-Signal peptide peptidase-like 2B antibody - N-terminal (ab179691) at 1 µg/ml + 293T whole cell lysate at 10 µg

Anti-SPPL2B Antibody (aa53-102) - LS-C201482 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of Human 293T. SPPL2B antibody dilution 1.0 ug/ml.

Anti-SPPL2B Antibody (aa93-142) - LS-C80685 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
SPPL2B antibody LS-C80685 was used in IHC to stain formalin-fixed, paraffin-embedded human kidney.

Anti-SPPL2B antibody produced in rabbit - AV44989 from Sigma-Aldrich

Prices $316.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-SPPL2B: <B>Cat. No. AV44989</B>: Immunohistochemistry of SPPL2B in Human Kidney tissue with SPPL2B antibody at 4-8 μg/mL.

SPPL2B Antibody - N-terminal region (ARP44988_P050) - ARP44988_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

SPPL2B antibody - N-terminal region (ARP44989_P050) - ARP44989_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

SPPL2B antibody - 70R-6412 from Fitzgerald

Prices $345.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

SPPL2B Antibody - 31-372 from ProSci

Prices $315.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Antibody used in IHC on Human kidney.

SPPL2B Antibody - GWB-BAB23A from Genway Biotech

Prices $336.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-SPPL2B (aa 53-102) polyclonal antibody - DPABH-13142 from Creative Diagnostics

Host Rabbit
Clonality Polyclonal

SPPL2B-Antibody-Center - AP21609c from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 50 µl, 200 µl
Host Rabbit
Clonality Polyclonal
Anti-SPPL2B Antibody (Center)at 1:2000 dilution + human cerebellum lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 65 kDa Blocking/Dilution buffer: 5% NFDM/TBST.

SPPL2B-Antibody-N-Term - AP21660a from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 50 µl, 200 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-SPPL2B Antibody (N-Term) at 1:2000 dilution Lane 1: Hela whole cell lysate Lane 2: HT-29 whole cell lysate Lane 3: Jurkat whole cell lysate Lane 4: KG-1 whole cell lysate Lane 5: Ramos whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 65 kDa Blocking/Dilution buffer: 5% NFDM/TBST.

SPPL2B, Polyclonal Antibody - MBS839114 from MyBioSource

Prices $455.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

SPPL2B , Polyclonal Antibody - MBS9216642 from MyBioSource

Prices $155.00, $340.00
Sizes 50 µl, 200 µl
Host Rabbit
Clonality Polyclonal

SPPL2B , Polyclonal Antibody - MBS9215889 from MyBioSource

Prices $155.00, $340.00
Sizes 50 µl, 200 µl
Host Rabbit
Clonality Polyclonal

SPPL2B antibody - TA335377 from Acris Antibodies

Prices $325.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Host: Rabbit; Target Name: SPPL2B; Sample Tissue: 293T Whole cell lysates; Antibody Dilution: 1.0 ug/ml

SPPL2B antibody - TA335943 from Acris Antibodies

Prices $325.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
WB Suggested Anti-SPPL2B Antibody Titration: 1 ug/ml; Positive Control: Jurkat cell lysate;SPPL2B is supported by BioGPS gene expression data to be expressed in Jurkat

SPPL2B antibody - orb325199 from Biorbyt

Prices $502.00
Sizes 100 μl
Host Rabbit
Clonality Polyclonal

IMP4 antibody - orb157689 from Biorbyt

Prices $60.00, $128.00, $255.00, $340.00
Sizes 5 μg (Trial Size), 20 μg (Trial Size), 100 μg, 200 μg
Host Rabbit
Clonality Polyclonal

Anti-SPPL2B Antibody A07360 - A07360 from Boster Bio

Prices $299.00
Sizes 1
Host Rabbit
Clonality Polyclonal
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