ZBTB7B
| Gene Symbol | ZBTB7B |
|---|---|
| Entrez Gene | 51043 |
| Alt Symbol | CKROX, THPOK, ZBTB15, ZFP-67, ZFP67, ZNF857B, c-KROX, hcKROX |
| Species | Human |
| Gene Type | protein-coding |
| Description | zinc finger and BTB domain containing 7B |
| Other Description | T-helper-inducing POZ/Krueppel-like factor|krueppel-related zinc finger protein cKrox|zinc finger and BTB domain containing 15|zinc finger and BTB domain-containing protein 7B|zinc finger protein 67 homolog|zinc finger protein 857B|zinc finger protein Th-POK |
| Swissprots | D3DV83 J3KQQ3 Q96EP2 Q68DR2 B4E3K5 O15156 |
| Accessions | EAW53149 EAW53150 EAW53151 O15156 AF007833 AAC51847 AI270090 AK127884 AK291619 BAF84308 AK304762 BAG65517 AW663133 BC012070 AAH12070 BC128176 BF510901 BM801567 BX114870 CK820289 CR749303 CAH18158 CV572166 DA970906 DB241444 EU446494 ABZ92023 EU832462 ACE87634 EU832510 ACE87682 EU832516 ACE87688 EU832544 ACE86946 EU832591 ACE86993 EU832597 ACE86999 XM_006711349 XP_006711412 XM_006711353 XP_006711416 XM_006711354 XP_006711417 XM_006711356 XP_006711419 XM_006711357 XP_006711420 XM_006711358 XP_006711421 XM_006711359 XP_006711422 XM_011509598 XP_011507900 XM_011509599 XP_011507901 NM_001252406 NP_001239335 NM_001256455 NP_001243384 NR_045515 NR_046206 NR_049765 |
| Function | Transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. Necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. Transcriptional repressor of the collagen COL1A1 and COL1A2 genes. May also function as a repressor of fibronectin and possibly other extracellular matrix genes (By similarity). {ECO:0000250}. |
| Subcellular Location | Nucleus. |
TH-POK CRISPR/Cas9 KO Plasmid (h) - sc-417566 from Santa Cruz Biotechnology
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TH-POK HDR Plasmid (h) - sc-417566-HDR from Santa Cruz Biotechnology
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TH-POK Double Nickase Plasmid (h) - sc-417566-NIC from Santa Cruz Biotechnology
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TH-POK Double Nickase Plasmid (h2) - sc-417566-NIC-2 from Santa Cruz Biotechnology
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TH-POK CRISPR Activation Plasmid (h) - sc-417566-ACT from Santa Cruz Biotechnology
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TH-POK CRISPR Activation Plasmid (h2) - sc-417566-ACT-2 from Santa Cruz Biotechnology
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TH-POK Lentiviral Activation Particles (h) - sc-417566-LAC from Santa Cruz Biotechnology
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TH-POK Lentiviral Activation Particles (h2) - sc-417566-LAC-2 from Santa Cruz Biotechnology
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TH-POK siRNA (h) - sc-76649 from Santa Cruz Biotechnology
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TH-POK shRNA Plasmid (h) - sc-76649-SH from Santa Cruz Biotechnology
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TH-POK shRNA (h) Lentiviral Particles - sc-76649-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU071621 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN23086 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND23086 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01645 from Sigma-Aldrich
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ZBTB7B siRNA (Human) - CRH9475 from Cohesion Biosciences
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Th-POK RNAi - H00051043-R01 from Novus Biologicals
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ZBTB7B - MBS8236006 from MyBioSource
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Human ZBTB7B siRNA - orb269977 from Biorbyt
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ZBTB7B shRNA Plasmid (Human) - CHH9475 from Cohesion Biosciences
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