MAD1L1

Gene Symbol	MAD1L1
Entrez Gene	8379
Alt Symbol	MAD1, PIG9, TP53I9, TXBP181
Species	Human
Gene Type	protein-coding
Description	MAD1 mitotic arrest deficient-like 1 (yeast)
Other Description	MAD1-like protein 1|mitotic arrest deficient 1-like protein 1|mitotic checkpoint MAD1 protein homolog|mitotic spindle assembly checkpoint protein MAD1|mitotic-arrest deficient 1, yeast, homolog-like 1|tax-binding protein 181|tumor protein p53 inducible protein 9
Swissprots	Q9UNH0 Q9Y6D9 Q86UM4 Q13312 B3KR41 Q75MI0
Accessions	AAP21876 AAS07503 EAL23947 EAW87219 EAW87220 Q9Y6D9 AF083811 AAD24498 AF123318 AAD20359 AK090959 BAG52253 AK310481 AK310831 AK314227 BC009964 AAH09964 BC018870 BG762406 BM818088 BQ684437 BQ687750 BU617803 EU831486 ACE87173 EU831573 ACE86492 U33822 AAC52059 XM_005249877 XP_005249934 XM_011515567 XP_011513869 XM_011515568 XP_011513870 XM_011515569 XP_011513871 XM_011515570 XP_011513872 XM_011515571 XP_011513873 NM_001013836 NP_001013858 NM_001013837 NP_001013859 NM_001304523 NP_001291452 NM_001304524 NP_001291453 NM_001304525 NP_001291454 NM_003550 NP_003541
Function	Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. May recruit MAD2L1 to unattached kinetochores. Has a role in the correct positioning of the septum. Required for anchoring MAD2L1 to the nuclear periphery. Binds to the TERT promoter and represses telomerase expression, possibly by interfering with MYC binding. {ECO:0000269|PubMed:10049595, ECO:0000269|PubMed:12837246, ECO:0000269|PubMed:20133940}.
Subcellular Location	Nucleus. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=From the beginning to the end of mitosis, it is seen to move from a diffusely nuclear distribution to the centrosome, to the spindle midzone and finally to the midbody. Colocalizes with NEK2 at the kinetochore.
Tissue Specificity	Expressed weakly at G0/G1 and highly at late S and G2/M phase.
Top Pathways	Cell cycle, Progesterone-mediated oocyte maturation, Viral carcinogenesis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human MAD1 protein fragment - ab160009 from Abcam Category Protein Source Wheat germ Species Human

MAD1L1 / MAD1 Antibody Blocking Peptide - LS-E1601 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MAD1L1 / MAD1 Antibody Blocking Peptide - LS-E23204 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human MAD1L1/MAD1 Protein - H00008379-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

MAD1L1-Antibody-N-term-Blocking-peptide - BP12347a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

MAD1L1 - H00008379-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

MAD1L1 - H00008379-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

MAD1L1 fusion protein - Ag13153 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

MAD1L1 fusion protein - ag13171 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human MAD1L1, His-tagged - MAD1L1-682H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Mitotic spindle assembly checkpoint protein MAD1(MAD1L1) - CSB-YP897310HU CSB-EP897310HU CSB-BP897310HU CSB-MP897310HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Mad 1 (1-221) - sc-4086 WB from Santa Cruz Biotechnology Category Protein Prices $88.00 Sizes 10 µg/0.1 ml Species Human

MAD1L1 (transcript variant 1) - TP303471 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

MAD1L1 (transcript variant 2) - TP322718 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

MAD1L1/MAD1 Protein - NBP1-89664PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

MAD1L1 Peptide, Human - M34GP09062H from Creative Peptides Category Peptide Source Synthetic. Species Human

Mitotic spindle assembly checkpoint protein MAD1 (MAD1L1), Recombinant Protein - MBS1327396 from MyBioSource Category Protein Prices $1,525.00, $1,525.00, $1,755.00, $1,755.00, $2,620.00, $2,620.00, $3,060.00, $3,060.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Recombinant Human MAD1L1 Protein, MYC/DDK-tagged - MAD1L1-176H from Creative Biomart Category Protein Source HEK293 Species Human

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