| Gene Symbol |
PLXDC1
|
| Entrez Gene |
57125
|
| Alt Symbol |
TEM3, TEM7
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
plexin domain containing 1
|
| Other Description |
2410003I07Rik|plexin domain-containing protein 1|tumor endothelial marker 3|tumor endothelial marker 7
|
| Swissprots |
Q8IUK5 Q5QCZ7 Q5QCZ9 Q5QCZ8 Q9HCT9 B2R7I8
|
| Accessions |
EAW60551 EAW60552 EAW60553 Q8IUK5 AF070526 AF279144 AAG00869 AF378753 AAL11990 AK093589 BAG52742 AK127539 BAC87025 AK303699 BAG64685 AK312999 BAG35835 AL833517 AY704670 AAV85657 AY704671 AAV85658 AY704672 AAV85659 BC036059 AAH36059 DA205327 EU832116 ACE87466 EU832210 ACE86780 NM_020405 NP_065138
|
| Function |
Plays a critical role in endothelial cell capillary morphogenesis. {ECO:0000250}.
|
| Subcellular Location |
Isoform 3: Secreted {ECO:0000305}.
|
| Tissue Specificity |
Detected in endothelial cells from colorectal cancer, and in endothelial cells from primary cancers of the lung, liver, pancreas, breast and brain. Not detectable in endothelial cells from normal tissue. Expressed in fibrovascular membrane with increased expression in individuals with proliferative diabetic retinopathy. {ECO:0000269|PubMed:10947988, ECO:0000269|PubMed:11559528, ECO:0000269|PubMed:17560052, ECO:0000269|PubMed:18316703}.
|