Gene Symbol | TPCN1 |
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Entrez Gene | 53373 |
Alt Symbol | TPC1 |
Species | Human |
Gene Type | protein-coding |
Description | two pore segment channel 1 |
Other Description | two pore calcium channel protein 1|two-pore channel 1|two-pore segment channel 1|voltage-dependent calcium channel protein TPC1 |
Swissprots | Q8NC20 Q86XS9 A7E258 Q9ULQ1 |
Accessions | EAW98046 EAW98047 Q9ULQ1 AB032995 BAA86483 AK000619 BAA91290 AK025838 AK057414 AK075071 BAC11385 AK093490 BAG52729 AK295022 BAH11951 AK296268 BAH12298 AY083666 AAM01199 BC007419 BC068001 BC069234 BC110885 BC136795 AAI36796 BC136796 AAI36797 BC142664 AAI42665 BC150203 AAI50204 BC152423 AAI52424 DA777641 XM_005253905 XP_005253962 XM_005253906 XP_005253963 XM_011538489 XP_011536791 XM_011538490 XP_011536792 XM_011538492 XP_011536794 XM_011538493 XP_011536795 XM_011538494 XP_011536796 XR_243017 NM_001143819 NP_001137291 NM_001301214 NP_001288143 NM_017901 NP_060371 |
Function | Nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major voltage-gated Ca(2+) channels (VDCC) across the lysosomal and endosomal membrane. {ECO:0000269|PubMed:19620632}. |
Subcellular Location | Lysosome membrane {ECO:0000269|PubMed:19620632}; Multi-pass membrane protein {ECO:0000269|PubMed:19620632}. Endosome membrane {ECO:0000269|PubMed:19620632}; Multi-pass membrane protein {ECO:0000269|PubMed:19620632}. |
Tissue Specificity | Highest expression found in the heart and kidney, and lowest expression found in the spleen. {ECO:0000269|PubMed:10574461}. |
TPCN1 CRISPR/Cas9 KO Plasmid (h) - sc-404943 from Santa Cruz Biotechnology
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TPCN1 HDR Plasmid (h) - sc-404943-HDR from Santa Cruz Biotechnology
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TPCN1 Double Nickase Plasmid (h) - sc-404943-NIC from Santa Cruz Biotechnology
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TPCN1 Double Nickase Plasmid (h2) - sc-404943-NIC-2 from Santa Cruz Biotechnology
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TPCN1 CRISPR Activation Plasmid (h) - sc-404943-ACT from Santa Cruz Biotechnology
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TPCN1 CRISPR Activation Plasmid (h2) - sc-404943-ACT-2 from Santa Cruz Biotechnology
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TPCN1 Lentiviral Activation Particles (h) - sc-404943-LAC from Santa Cruz Biotechnology
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TPCN1 Lentiviral Activation Particles (h2) - sc-404943-LAC-2 from Santa Cruz Biotechnology
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TPCN1 siRNA (h) - sc-63141 from Santa Cruz Biotechnology
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TPCN1 shRNA Plasmid (h) - sc-63141-SH from Santa Cruz Biotechnology
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TPCN1 shRNA (h) Lentiviral Particles - sc-63141-V from Santa Cruz Biotechnology
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TPCN1 RNAi - H00053373-R01 from Novus Biologicals
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MISSION® esiRNA - EHU016301 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN21857 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21857 from Sigma-Aldrich
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TPCN1 siRNA (Human) - CRH9971 from Cohesion Biosciences
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TPCN1 - MBS8233676 from MyBioSource
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shRNA set against Human TPCN1 (NM_017901.4) - SHH433188 from Creative biogene
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Human TPCN1 siRNA - orb270473 from Biorbyt
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TPCN1 shRNA Plasmid (Human) - CHH9971 from Cohesion Biosciences
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TPCN1 miRNA 3'UTR clone - MiUTR4H-TG09282 from Creative biogene
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