Gene Symbol | HIST1H2BK |
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Entrez Gene | 85236 |
Alt Symbol | H2B/S, H2BFAiii, H2BFT, H2BK |
Species | Human |
Gene Type | protein-coding |
Description | histone cluster 1, H2bk |
Other Description | H2B K|H2B histone family, member T|HIRA-interacting protein 1|histone 1, H2bk|histone H2B type 1-K|histone family member |
Swissprots | A8K7P7 O60814 Q2VPI7 |
Accessions | AAN06694 EAX03084 EAX03085 O60814 AJ223352 CAA11276 AK292062 BAF84751 BC000893 AAH00893 BC051872 AAH51872 BC064959 AAH64959 BC108737 AAI08738 DA873786 EU446970 ABZ92499 NM_080593 NP_542160 |
Function | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
Subcellular Location | Nucleus. Chromosome. |
Top Pathways | Systemic lupus erythematosus, Viral carcinogenesis, Alcoholism |
Histone cluster 1 H2BK CRISPR/Cas9 KO Plasmid (h) - sc-417678 from Santa Cruz Biotechnology
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Histone cluster 1 H2BK HDR Plasmid (h) - sc-417678-HDR from Santa Cruz Biotechnology
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Histone cluster 1 H2BK Double Nickase Plasmid (h) - sc-417678-NIC from Santa Cruz Biotechnology
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Histone cluster 1 H2BK Double Nickase Plasmid (h2) - sc-417678-NIC-2 from Santa Cruz Biotechnology
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Histone cluster 1 H2BK CRISPR Activation Plasmid (h) - sc-417678-ACT from Santa Cruz Biotechnology
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Histone cluster 1 H2BK CRISPR Activation Plasmid (h2) - sc-417678-ACT-2 from Santa Cruz Biotechnology
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Histone cluster 1 H2BK Lentiviral Activation Particles (h) - sc-417678-LAC from Santa Cruz Biotechnology
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Histone cluster 1 H2BK Lentiviral Activation Particles (h2) - sc-417678-LAC-2 from Santa Cruz Biotechnology
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Histone cluster 1 H2BK siRNA (h) - sc-105481 from Santa Cruz Biotechnology
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Histone cluster 1 H2BK shRNA Plasmid (h) - sc-105481-SH from Santa Cruz Biotechnology
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Histone cluster 1 H2BK shRNA (h) Lentiviral Particles - sc-105481-V from Santa Cruz Biotechnology
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HIST1H2BK RNAi - H00085236-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN10078 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10078 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02990 from Sigma-Aldrich
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HIST1H2BK siRNA (Human) - CRJ3764 from Cohesion Biosciences
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HIST1H2BK - MBS828111 from MyBioSource
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shRNA set against Human HIST1H2BK (NM_080593.2) - SHH312633 from Creative biogene
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Human HIST1H2BK siRNA - orb274265 from Biorbyt
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HIST1H2BK shRNA Plasmid (Human) - CHJ3764 from Cohesion Biosciences
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HIST1H2BK miRNA 3'UTR clone - MiUTR3H-15068 from Creative biogene
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