| Gene Symbol |
PCNA
|
| Entrez Gene |
515499
|
| Alt Symbol |
-
|
| Species |
Bovine
|
| Gene Type |
protein-coding
|
| Description |
proliferating cell nuclear antigen
|
| Other Description |
-
|
| Swissprots |
Q3ZBW4
|
| Accessions |
DAA23435 Q3ZBW4 BC103068 AAI03069 NM_001034494 NP_001029666
|
| Function |
Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'- 5' exonuclease and 3'-phosphodiesterase, but not apurinic- apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways. Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion (By similarity). {ECO:0000250
|
| Subcellular Location |
Nucleus {ECO:0000250}. Note=Forms nuclear foci representing sites of ongoing DNA replication and vary in morphology and number during S phase. Together with APEX2, is redistributed in discrete nuclear foci in presence of oxidative DNA damaging agents (By similarity). {ECO:0000250}.
|
| Top Pathways |
DNA replication, Mismatch repair, Cell cycle, Base excision repair, Nucleotide excision repair
|
