| Gene Symbol | PCNA |
|---|---|
| Entrez Gene | 515499 |
| Alt Symbol | - |
| Species | Bovine |
| Gene Type | protein-coding |
| Description | proliferating cell nuclear antigen |
| Other Description | - |
| Swissprots | Q3ZBW4 |
| Accessions | DAA23435 Q3ZBW4 BC103068 AAI03069 NM_001034494 NP_001029666 |
| Function | Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'- 5' exonuclease and 3'-phosphodiesterase, but not apurinic- apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways. Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion (By similarity). {ECO:0000250 |
| Subcellular Location | Nucleus {ECO:0000250}. Note=Forms nuclear foci representing sites of ongoing DNA replication and vary in morphology and number during S phase. Together with APEX2, is redistributed in discrete nuclear foci in presence of oxidative DNA damaging agents (By similarity). {ECO:0000250}. |
| Top Pathways | DNA replication, Mismatch repair, Cell cycle, Base excision repair, Nucleotide excision repair |
Recombinant Bovine Proliferating cell nuclear antigen(PCNA) - CSB-YP017621BO CSB-EP017621BO CSB-BP017621BO CSB-MP017621BO from Cusabio
|
||||||||||
Proliferating cell nuclear antigen (PCNA), Recombinant Protein - MBS1409846 from MyBioSource
|