Disc1
| Gene Symbol | Disc1 |
|---|---|
| Entrez Gene | 307940 |
| Alt Symbol | - |
| Species | Rat |
| Gene Type | protein-coding |
| Description | disrupted in schizophrenia 1 |
| Other Description | disrupted in schizophrenia 1 homolog |
| Swissprots | Q810H6 |
| Accessions | EDL96753 Q810H6 AY177674 AAO19642 XM_008772616 XP_008770838 NM_175596 NP_783186 |
| Function | Involved in the regulation of multiple aspects of embryonic and adult neurogenesis. Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus. Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance. Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation. Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A. Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development. Plays a role, together with PCNT, in the microtubule network formation. {ECO:0000269|PubMed:17035248}. |
| Subcellular Location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Note=Colocalizes with PCNT at the centrosome (By similarity). Localizes to punctate cytoplasmic foci which may overlap in part with mitochondria. Colocalizes with NDEL1 in the perinuclear region and the centrosome. {ECO:0000250}. |
| Tissue Specificity | Expressed in brain, heart, kidney, liver and thymus. Within the brain expression is high in the cerebral cortex, hippocampus and olfactory bulb and is also seen at lower levels in the cerebellum. {ECO:0000269|PubMed:12506198}. |
Anti-DISC1 antibody - ab133017 from Abcam
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DISC1 Antibody - NB110-40773 from Novus Biologicals
![Immunocytochemistry/Immunofluorescence: DISC1 Antibody [NB110-40773] - DISC1 antibody was tested in PC-12 cells at 1:100 with Dylight 488 (green). Nuclei and alpha-tubulin were counterstained with DAPI (blue) and Dylight 549 (red).](http://www.bioprodhub.com/system/product_images/ab_products/5/sub_7/12010_DISC1-Antibody-Immunocytochemistry-Immunofluorescence-NB110-40773-img0006.jpg)
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DISC1 Antibody [HRP] - NB110-40773H from Novus Biologicals
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DISC1 Antibody [Biotin] - NB110-40773B from Novus Biologicals
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DISC1 Antibody [DyLight 650] - NB110-40773C from Novus Biologicals
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DISC1 Antibody [DyLight 488] - NB110-40773G from Novus Biologicals
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DISC1 Antibody [DyLight 550] - NB110-40773R from Novus Biologicals
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DISC1 Antibody [FITC] - NB110-40773F from Novus Biologicals
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DISC1 Antibody [DyLight 405] - NB110-40773V from Novus Biologicals
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DISC1 Antibody [Alexa Fluor (R) 405] - NB110-40773AF405 from Novus Biologicals
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DISC1 Antibody [Alexa Fluor (R) 700] - NB110-40773AF700 from Novus Biologicals
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DISC1 Antibody [Alexa Fluor (R) 647] - NB110-40773AF647 from Novus Biologicals
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DISC1 Antibody [Alexa Fluor (R) 488] - NB110-40773AF488 from Novus Biologicals
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Anti -DISC1 (Disrupted in Schizophrenia 1, RP4-730B13.1, KIAA0457, SCZD9) - D8066-83A from USBiological Life Science
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Anti -Disrupted In Schizophrenia 1 (DISC1) - 151735 from USBiological Life Science
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Anti -Disrupted In Schizophrenia 1 (DISC1) (AP) - 151735-AP from USBiological Life Science
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Anti -Disrupted In Schizophrenia 1 (DISC1) (APC) - 151735-APC from USBiological Life Science
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Anti -Disrupted In Schizophrenia 1 (DISC1) (Biotin) - 151735-Biotin from USBiological Life Science
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Anti -Disrupted In Schizophrenia 1 (DISC1) (FITC) - 151735-FITC from USBiological Life Science
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Anti -Disrupted In Schizophrenia 1 (DISC1) (HRP) - 151735-HRP from USBiological Life Science
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Anti -Disrupted In Schizophrenia 1 (DISC1) (PE) - 151735-PE from USBiological Life Science
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DISC1 Antibody - abx102997 from Abbexa
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DISC1 antibody - PAB12110 from Acris Antibodies
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Rabbit anti-Rat DISC1 polyclonal antibody - DPABH-29212 from Creative Diagnostics
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Disrupted In Schizophrenia 1 (DISC1) Polyclonal Antibody - CAU24481 from Biomatik
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