| Gene Symbol |
Disc1
|
| Entrez Gene |
307940
|
| Alt Symbol |
-
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
disrupted in schizophrenia 1
|
| Other Description |
disrupted in schizophrenia 1 homolog
|
| Swissprots |
Q810H6
|
| Accessions |
EDL96753 Q810H6 AY177674 AAO19642 XM_008772616 XP_008770838 NM_175596 NP_783186
|
| Function |
Involved in the regulation of multiple aspects of embryonic and adult neurogenesis. Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus. Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance. Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation. Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A. Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development. Plays a role, together with PCNT, in the microtubule network formation. {ECO:0000269|PubMed:17035248}.
|
| Subcellular Location |
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Note=Colocalizes with PCNT at the centrosome (By similarity). Localizes to punctate cytoplasmic foci which may overlap in part with mitochondria. Colocalizes with NDEL1 in the perinuclear region and the centrosome. {ECO:0000250}.
|
| Tissue Specificity |
Expressed in brain, heart, kidney, liver and thymus. Within the brain expression is high in the cerebral cortex, hippocampus and olfactory bulb and is also seen at lower levels in the cerebellum. {ECO:0000269|PubMed:12506198}.
|