BIRC2

Gene Symbol BIRC2
Entrez Gene 329
Alt Symbol API1, HIAP2, Hiap-2, MIHB, RNF48, c-IAP1, cIAP1
Species Human
Gene Type protein-coding
Description baculoviral IAP repeat containing 2
Other Description IAP homolog B|IAP-2|NFR2-TRAF signalling complex protein|RING finger protein 48|TNFR2-TRAF-signaling complex protein 2|apoptosis inhibitor 1|baculoviral IAP repeat-containing 2|baculoviral IAP repeat-containing protein 2|inhibitor of apoptosis protein 2
Swissprots B4E026 Q16516 Q13490 Q4TTG0
Accessions AAY46158 EAW67018 Q13490 AK225856 AK303197 BAG64288 AK313446 BAG36235 BC016174 AAH16174 BC028578 AAH28578 BX647978 DA094075 DA115985 DQ892384 ABM83310 DQ895596 ABM86522 L49431 AAC41942 U37547 AAC50508 U45879 AAC50372 NM_001166 NP_001157 NM_001256163 NP_001243092 NM_001256166 NP_001243095
Function Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin- protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin- protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF2, DIABLO/SMAC, MAP3K14/NIK, MAP3K5/ASK1, IKBKG/NEMO, IKBKE and MXD1/MAD1. Can also function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptor
Subcellular Location Cytoplasm. Nucleus. Note=Agents that induce either the extrinsic or intrinsic apoptotic pathways promote its redistribution from the nuclear compartment to the cytoplasmic compartment. Associated with the midbody in telophase cells, and found diffusely in the nucleus of interphase cells.
Tissue Specificity Present in many fetal and adult tissues. Mainly expressed in adult skeletal muscle, thymus, testis, ovary, and pancreas, low or absent in brain and peripheral blood leukocytes.
Top Pathways NOD-like receptor signaling pathway, TNF signaling pathway, Hippo signaling pathway, Toxoplasmosis, Apoptosis

c-IAP1 (D5G9) Rabbit mAb - 7065 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D5G9
Western blot analysis of extracts from various cell lines using c-IAP1 (D5G9) Rabbit mAb.

c-IAP1 Antibody - 4952 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from Jurkat, HeLa, and HT29 cells, using c-IAP1 Antibody.

c-IAP1 (F-4) - sc-271419 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
c-IAP1 (F-4): sc-271419. Western blot analysis of c-IAP1 expression in MOLT-4 (A), K-562 (B) and Raji (C) whole cell lysates.

c-IAP1 (H-83) - sc-7943 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
c-IAP1 (H-83): sc-7943. Western blot analysis of c-IAP1 expression in Jurkat (A) and MOLT-4 (B) whole cell lysates.

c-IAP1 (N-19) - sc-1867 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

c-IAP1/2 (A-13) - sc-12410 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
c-IAP1/2 (A-13): sc-12410. Western blot analysis of c-IAP1/2 expression in mouse (A) and rat (B) testis tissue extracts.

Anti-cIAP1 antibody - ab2399 from Abcam

Prices $382.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-cIAP1 antibody (ab2399) + Jurkat Cell lysate

Anti-cIAP1 antibody - ab189193 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-cIAP1 antibody (ab189193) at 4 µg/ml + Mouse small intestine extracts

Anti-cIAP1 antibody - ab154525 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-cIAP1 antibody (ab154525) at 1/1000 dilution + rat muscle lysate at 50 µg

Anti-cIAP1 antibody - ab123424 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-cIAP1 antibody (ab123424) at 1/100 dilution + MDA-MB231 cell line lysate at 35 µg

Anti-cIAP1 antibody [1D9-H6-D7] - ab150770 from Abcam

Host Mouse
Clonality Monoclonal
Clone 1D9-H6-D7
Anti-cIAP1 antibody [1D9-H6-D7] (ab150770) at 1/1000 dilution + K562 cell lysates

Anti-cIAP1 antibody [EPR4673] - ab108361 from Abcam

Prices $381.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4673
All lanes : Anti-cIAP1 antibody [EPR4673] (ab108361) at 1/1000 dilutionLane 1 : Jurkat cell lysate Lane 2 : HeLa cell lysate Lane 3 : HT29 cell lysateLane 4 : HepG2 cell lysate Lysates/proteins at 10 µg per lane.

Anti-cIAP1 antibody [MM0697-11R30] - ab201588 from Abcam

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone MM0697-11R30

Anti-cIAP1 antibody - N-terminal - ab196592 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded human stomach cancer tissue labeling cIAP1 using ab196592 at a 1/200 dilution.

Anti-BIRC2 / cIAP1 Antibody - LS-C192309 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of BIRC2 pAb in extracts from Jurkat, Hela and HT29 cells.

Anti-BIRC2 / cIAP1 Antibody - LS-C148258 from LifeSpan Bioscience

Prices $335.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
IHC of cIAP1 in formalin-fixed, paraffin-embedded human prostate using LS-C148258 at 1:2000. A, normal prostate. B, prostate intraepithelial neoplasia (PIN). PIN is a premalignant proliferation arising within the prostate. C, prostate cancer. Hematoxylin-Eosin counterstain. Increased cIAP1 expression is PIN and in prostate cancer compared to normal prostate.

Anti-BIRC2 / cIAP1 Antibody (aa215-244, FITC) - LS-C252579 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-BIRC2 / cIAP1 Antibody (aa215-244, Biotin) - LS-C252580 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-BIRC2 / cIAP1 Antibody (aa2-18) - LS-C148259 from LifeSpan Bioscience

Prices $335.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
IHC of formalin-fixed, paraffin-embedded human breast tissue using LS-C148259 at 1:2000. A, normal breast tissue. B, ductal carcinoma in situ (DCIS). C, invasive breast carcinoma. A1, B1, and C1 are higher magnifications of A, B and C, respectively. Hematoxylin-Eos in counterstain. IncreasedcIAP1 expression is seen in the cancerous compared to normal breast tissue. Hematoxylin-Eos in counterstain.

Anti-BIRC2 / cIAP1 Antibody (aa215-244, PE) - LS-C252581 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-BIRC2 / cIAP1 Antibody (aa215-244, Azide-free, HRP) - LS-C252582 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-BIRC2 / cIAP1 Antibody (C-Terminus) IHC-plus™ - LS-B179 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-cIAP1 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B179 concentration 5 ug/ml.

Anti-BIRC2 / cIAP1 Antibody (aa215-244) - LS-C156820 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
BIRC2 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human kidney tissue followed by peroxidase-conjugated secondary antibody and DAB staining.

Anti-BIRC2 / cIAP1 Antibody (aa148-298, Biotin) - LS-C301189 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-BIRC2 / cIAP1 Antibody (aa148-298, FITC) - LS-C303910 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
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