BIRC2

Gene Symbol	BIRC2
Entrez Gene	329
Alt Symbol	API1, HIAP2, Hiap-2, MIHB, RNF48, c-IAP1, cIAP1
Species	Human
Gene Type	protein-coding
Description	baculoviral IAP repeat containing 2
Other Description	IAP homolog B|IAP-2|NFR2-TRAF signalling complex protein|RING finger protein 48|TNFR2-TRAF-signaling complex protein 2|apoptosis inhibitor 1|baculoviral IAP repeat-containing 2|baculoviral IAP repeat-containing protein 2|inhibitor of apoptosis protein 2
Swissprots	B4E026 Q16516 Q13490 Q4TTG0
Accessions	AAY46158 EAW67018 Q13490 AK225856 AK303197 BAG64288 AK313446 BAG36235 BC016174 AAH16174 BC028578 AAH28578 BX647978 DA094075 DA115985 DQ892384 ABM83310 DQ895596 ABM86522 L49431 AAC41942 U37547 AAC50508 U45879 AAC50372 NM_001166 NP_001157 NM_001256163 NP_001243092 NM_001256166 NP_001243095
Function	Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin- protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin- protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF2, DIABLO/SMAC, MAP3K14/NIK, MAP3K5/ASK1, IKBKG/NEMO, IKBKE and MXD1/MAD1. Can also function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptor
Subcellular Location	Cytoplasm. Nucleus. Note=Agents that induce either the extrinsic or intrinsic apoptotic pathways promote its redistribution from the nuclear compartment to the cytoplasmic compartment. Associated with the midbody in telophase cells, and found diffusely in the nucleus of interphase cells.
Tissue Specificity	Present in many fetal and adult tissues. Mainly expressed in adult skeletal muscle, thymus, testis, ovary, and pancreas, low or absent in brain and peripheral blood leukocytes.
Top Pathways	NOD-like receptor signaling pathway, TNF signaling pathway, Hippo signaling pathway, Toxoplasmosis, Apoptosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human BIRC2 / cIAP1 ELISA Kit (Sandwich ELISA) - LS-F10942 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 78 Range 78-5000 pg/ml

Human cIAP-1/HIAP-2 Ubiquitin Ligase Kit - K-260 from R&D Systems Prices $355.00 Sizes 1 kit

Baculoviral IAP repeat-containing protein 2 (BIRC2), Human, ELISA Kit - CSB-EL002703HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Baculoviral IAP repeat-containing protein 2 (BIRC2), Human, ELISA Kit - E01B0799 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

Baculoviral IAP repeat-containing protein 2, BIRC2, Human, ELISA Kit - E10854h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 78-5000 pg/mL

Baculoviral IAP repeat containing protein 2 (BIRC2), ELISA Kit - MBS7217561 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

baculoviral IAP repeat-containing 2, ELISA Kit - MBS947693 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of human BIRC2 is typically less than 5.8 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. Range 23.5 pg/ml -1500 pg/ml.

Baculoviral IAP repeat-containing protein 2 (BIRC2), ELISA Kit - MBS7203868 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Baculoviral IAP repeat-containing protein 2 (BIRC2), ELISA Kit - MBS7200052 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Baculoviral IAP repeat-containing protein 2 (BIRC2), ELISA Kit - MBS7240020 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Baculoviral IAP repeat-containing protein 2 (BIRC2), ELISA Kit - MBS7222101 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Baculoviral IAP repeat-containing protein 2 (BIRC2), ELISA Kit - MBS7225429 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Baculoviral IAP repeat-containing protein 2 (BIRC2), ELISA Kit - MBS7223947 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Baculoviral IAP repeat-containing protein 2 (BIRC2), ELISA Kit - MBS7227791 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Baculoviral IAP repeat-containing protein 2 (BIRC2), ELISA Kit - MBS7208906 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Baculoviral IAP repeat-containing protein 2 (BIRC2), ELISA Kit - MBS7228654 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Baculoviral IAP repeat-containing protein 2 (BIRC2), ELISA Kit - MBS7229678 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Baculoviral IAP repeat-containing protein 2 (BIRC2), ELISA Kit - MBS7223024 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

baculoviral IAP repeat-containing protein 2/3 (BIRC2/3) , ELISA Kit - MBS9340986 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/ml Range 0.625 ng/ml - 20 ng/ml

Human Baculoviral IAP repeat-containing protein 2(BIRC2) ELISA kit - CSB-EL002703HU from Cusabio Category ELISA Kit Sensitivity 5.8 pg/ml Range 23.5 pg/ml-1500 pg/ml

Mouse BIRC2 / cIAP1 ELISA Kit (Custom ELISA) - LS-F15948 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 78-5000 pg/ml

Chicken BIRC2 / cIAP1 ELISA Kit (Custom ELISA) - LS-F16207 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity To be determined Range 78-5000 pg/ml

cIAP-1/HIAP2 Ubiquitin Ligase Kit - K-260 from Boston Biochem Prices $355.00 Sizes 1 kit

Custom Human cIAP-1 ELISA - ELH-CIAP1 from RayBiotech Category ELISA Kit Prices $615.00, $1,107.00, $2,460.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit

Human cIAP-1 ELISA Kit - orb319919 from Biorbyt Category ELISA Kit Prices $1,148.00, $1,981.00, $4,284.00 Sizes 96 assays, 192 assays, 480 assays

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