RUNX1

Gene Symbol RUNX1
Entrez Gene 861
Alt Symbol AML1, AML1-EVI-1, AMLCR1, CBFA2, EVI-1, PEBP2aB
Species Human
Gene Type protein-coding
Description runt-related transcription factor 1
Other Description AML1-EVI-1 fusion protein|CBF-alpha-2|PEA2-alpha B|PEBP2-alpha B|SL3-3 enhancer factor 1 alpha B subunit|SL3/AKV core-binding factor alpha B subunit|acute myeloid leukemia 1 protein|core-binding factor, runt domain, alpha subunit 2|oncogene AML-1|polyomavirus enhancer-binding protein 2 alpha B subunit
Swissprots O60473 Q16347 O76089 Q16285 Q13757 Q01196 A8MV94 Q15341 Q15343 Q13755 B2RMS4 Q13756 Q16286 Q16346 O76047 Q13759 O60472 D3DSG1 Q13081 Q13758 Q92479 Q16284
Accessions AAC05246 AAC05247 AGY36885 CAA13070 EAX09769 EAX09770 Q01196 AA878154 AK226159 AK310587 AK310646 AL581043 AV761975 BC050363 BC110828 AAI10829 BC136380 AAI36381 BC136381 AAI36382 BC144053 AAI44054 BM149149 BX475024 CA503244 CD638998 D10570 BAA01426 D43967 BAA07902 D43968 BAA07903 D43969 BAA07904 D89788 BAA14020 D89789 BAA14021 D89790 BAA14022 KF041488 KF041489 L34598 AAA51720 S60998 S76345 AAB33729 S76346 AAB33730 S76350 AAB33731 U19601 AAB51691 X79549 CAA56092 X90976 CAA62464 X90977 X90979 CAA62466 X90980 CAA62467 X90981 CAA62468 XM_005261068 XP_005261125 XM_005261069 XP_005261126 XM_011529766 XP_011528068 XM_011529767 XP_011528069 XM_011529768 XP_011528070 XM_011529769 XP_011528071 XM_011529770 XP_011528072 XR_937576 NM_001001890 NP_001001890 NM_001122607 NP_001116079 NM_001754 NP_001745
Function CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL-3 and GM-CSF promoters. The alpha subunit binds DNA and appears to have a role in the development of normal hematopoiesis. Isoform AML-1L interferes with the transactivation activity of RUNX1. Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the mouse BLK promoter. Inhibits KAT6B- dependent transcriptional activation. Controls the anergy and suppressive function of regulatory T-cells (Treg) by associating with FOXP3. Activates the expression of IL2 and IFNG and down- regulates the expression of TNFRSF18, IL2RA and CTLA4, in conventional T-cells (PubMed:17377532). {ECO:0000269|PubMed:10207087, ECO:0000269|PubMed:11965546, ECO:0000269|PubMed:14970218, ECO:0000269|PubMed:17377532, ECO:0000269|PubMed:17431401}.
Subcellular Location Nucleus.
Tissue Specificity Expressed in all tissues examined except brain and heart. Highest levels in thymus, bone marrow and peripheral blood.
Top Pathways Chronic myeloid leukemia, Acute myeloid leukemia, Transcriptional misregulation in cancer

RUNX1 CRISPR/Cas9 KO Plasmid (h) - sc-400803 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

RUNX1 HDR Plasmid (h) - sc-400803-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RUNX1 Double Nickase Plasmid (h) - sc-400803-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RUNX1 Double Nickase Plasmid (h2) - sc-400803-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RUNX1 CRISPR Activation Plasmid (h) - sc-400803-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

RUNX1 CRISPR Activation Plasmid (h2) - sc-400803-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

RUNX1 Lentiviral Activation Particles (h) - sc-400803-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RUNX1 Lentiviral Activation Particles (h2) - sc-400803-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RUNX1 siRNA (h) - sc-37677 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

RUNX1 shRNA Plasmid (h) - sc-37677-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

RUNX1 shRNA (h) Lentiviral Particles - sc-37677-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU124231 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN18756 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18756 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

RUNX1 siRNA (Human) - CRH0606 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

RUNX1/CBFA2 RNAi - H00000861-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

RUNX1/CBFA2 RNAi - H00000861-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

RUNX1 - MBS8204372 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

RUNX1 CRISPR/Cas9 KO Plasmid (h2) - sc-400803-KO-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

RUNX1 HDR Plasmid (h2) - sc-400803-HDR-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

shRNA set against Human RUNX1 (NM_001754.4) - SHH400760 from Creative biogene

Category siRNA
Species Reactivities Human

Human RUNX1 siRNA - orb261108 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

RUNX1 shRNA Plasmid (Human) - CHH0606 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

RUNX1 miRNA 3'UTR clone - MiUTR3H-01303 from Creative biogene

Species Reactivities Human

RUNX1 miRNA 3'UTR clone - MiUTR3H-01304 from Creative biogene

Species Reactivities Human
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