| Gene Symbol |
Pttg1
|
| Entrez Gene |
30939
|
| Alt Symbol |
AW555095, C87862, Pttg, Pttg3
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
pituitary tumor-transforming gene 1
|
| Other Description |
pituitary tumor-transforming 1|pituitary tumor-transforming gene 1 protein|securin
|
| Swissprots |
Q9CQJ7 Q9Z2E6 O88887
|
| Accessions |
EDL33862 EDL33863 EDL33864 EDL33865 EDL33866 Q9CQJ7 AF069051 AAC62954 AF071209 AAC83236 AI790531 AK002473 BAB22127 AK008704 BAB25844 AK088387 BAC40321 BC023324 AAH23324 CN837307 DQ157177 AAZ83265 DV657646 XM_006533515 XP_006533578 XM_006533516 XP_006533579 NM_001131054 NP_001124526 NM_013917 NP_038945
|
| Function |
Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity and related apoptosis activity of p53/TP53. The negative regulation of p53/TP53 may explain the strong transforming capability of the protein when it is overexpressed. May also play a role in DNA repair via its interaction with Ku, possibly by connecting DNA damage-response pathways with sister chromatid separation (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
|
| Top Pathways |
Cell cycle, Oocyte meiosis, HTLV-I infection
|