Pttg1

Gene Symbol Pttg1
Entrez Gene 30939
Alt Symbol AW555095, C87862, Pttg, Pttg3
Species Mouse
Gene Type protein-coding
Description pituitary tumor-transforming gene 1
Other Description pituitary tumor-transforming 1|pituitary tumor-transforming gene 1 protein|securin
Swissprots Q9CQJ7 Q9Z2E6 O88887
Accessions EDL33862 EDL33863 EDL33864 EDL33865 EDL33866 Q9CQJ7 AF069051 AAC62954 AF071209 AAC83236 AI790531 AK002473 BAB22127 AK008704 BAB25844 AK088387 BAC40321 BC023324 AAH23324 CN837307 DQ157177 AAZ83265 DV657646 XM_006533515 XP_006533578 XM_006533516 XP_006533579 NM_001131054 NP_001124526 NM_013917 NP_038945
Function Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity and related apoptosis activity of p53/TP53. The negative regulation of p53/TP53 may explain the strong transforming capability of the protein when it is overexpressed. May also play a role in DNA repair via its interaction with Ku, possibly by connecting DNA damage-response pathways with sister chromatid separation (By similarity). {ECO:0000250}.
Subcellular Location Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Top Pathways Cell cycle, Oocyte meiosis, HTLV-I infection

PTTG CRISPR/Cas9 KO Plasmid (m) - sc-424422 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

PTTG HDR Plasmid (m) - sc-424422-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

PTTG Double Nickase Plasmid (m) - sc-424422-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

PTTG Double Nickase Plasmid (m2) - sc-424422-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

PTTG CRISPR Activation Plasmid (m) - sc-424422-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

PTTG CRISPR Activation Plasmid (m2) - sc-424422-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

PTTG Lentiviral Activation Particles (m) - sc-424422-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

PTTG Lentiviral Activation Particles (m2) - sc-424422-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

PTTG siRNA (m) - sc-37492 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

PTTG shRNA Plasmid (m) - sc-37492-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

PTTG shRNA (m) Lentiviral Particles - sc-37492-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

MISSION® esiRNA - EMU024971 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN39669 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND39669 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

PTTG1 siRNA (Mouse) - CRM5078 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

shRNA set against Mouse PTTG1 (NM_013917.2) - SHH386960 from Creative biogene

Category siRNA
Species Reactivities Mouse

shRNA set against Mouse Pttg1(NM_001131054.1) - SHR154446 from Creative biogene

Category siRNA
Species Reactivities Mouse

Mouse PTTG1 siRNA - orb284554 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

PTTG1 shRNA Plasmid (Mouse) - CHM5078 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Mouse

PTTG1 miRNA 3'UTR clone - MiUTR1M-09788 from Creative biogene

Species Reactivities Mouse
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